BACKGROUND Little is known regarding the clinical features of hereditary prostate
carcinoma (HPC) and whether other malignancies are associated with this disease. The aim …

Hereditary prostate cancer Page 1 Hereditary prostate cancer O. BRATT Department of Surgery,
Helsingborg Hospital, Helsingborg, Sweden Historical background and genetic principles …

Hereditary prostate cancer (HPC) is a genetically heterogeneous disease, complicating
efforts to map and clone susceptibility loci. We have used stratification of a large dataset of …

African American men have the highest incidence of prostate cancer in the world. Despite
this statistic, linkage studies designed to localise prostate cancer susceptibility alleles have …

Background A family history (FH) of prostate cancer (PrCa) is associated with an increased
likelihood of PrCa diagnosis. Conflicting evidence exists regarding familial PrCa and clinical …

The three most important recognized risks for prostate cancer (PCa) are increasing age,
ancestry, and family history of the disease. The clustering of PCa within families can be …

A previous linkage study provided evidence for a prostate cancer–susceptibility locus at
1q24-25. Subsequent reports in additional collections of families have yielded conflicting …

BACKGROUND Increased risk of prostate cancer among men with a family history of the
disease has been observed in several epidemiological studies, and family studies have …

Segregation analyses aim to detect genetic factors that have a major effect on an individual's
risk of disease and to describe them in terms of mode of inheritance, age-specific cumulative …

Prostate cancer occurs more frequently in US blacks than whites. A population‐based case‐
control study which investigated the association with family history of cancer was carried out …