Covering: up to the end of 2011 This review covers classical and modern structural
modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and …

Cytisine, a natural bioactive compound that is mainly isolated from plants of the
Leguminosae family (especially the seeds of Laburnum anagyroides), has been marketed in …

Cytisine, a natural plant alkaloid, has been marketed in Central and Eastern Europe for over
40 years for the clinical management of smoking cessation. Despite the fact that cytisine has …

Neuronal nicotinic acetylcholine receptors subserve predominantly modulatory roles in the
brain, making them attractive therapeutic targets. Natural products provide key leads in the …

Thirty-one N-derivatives of cytisine were prepared in order to modify its pharmacological
profile and to obtain compounds of potential therapeutic interest either at a peripheral or …

Neuronal nicotinic acetylcholine receptors (nAChRs) form a family of ACh-gated cation
channels made up of different subtypes. They are widely distributed in peripheral and …

(−)-Cytisine (−)-1,[(1R, 5S)-1, 2, 3, 4, 5, 6-hexahydro-1, 5-methano-8H-pyrido [1, 2a][1, 5]
diazocin-8-one (Figure 1), is an alkaloid extracted from various plants belonging to the …

Cigarette smoking is the one of the prevalent risk factors for morbidity in the world. The
treatment of smoking is rapidly changing. Alternative approaches to the nicotine …

In order to test (−)-cytisine as a potential chiral inductor, N-propionyl cytisine was treated
with LDA and then with benzyl bromide. Instead of the expected α-benzyl substituted …

Am Kern der Sache: Eine modulare und robuste Synthese von Cytisin, einem selektiven
Partialagonisten des nikotinischen α4β2‐Acetylcholinrezeptors, ermöglicht auch die …