Inflammasomes, multiprotein complex induced by harmful factors in the body, play a crucial
role in innate immunity. Activation of inflammasomes lead to the activation of casepase-1 …

Renal fibrosis is a common pathological process where certain primary or secondary kidney
diseases can continue to progress to the end-stage of the kidney disease; however, the …

Chronic kidney disease (CKD) is a global health concern and public health priority. The
condition often involves inflammation due to the accumulation of toxins and the reduced …

Metabolic syndrome (MS) is a group of complex metabolic disorders syndrome, which refers
to the pathological state of metabolism disorder of protein, fat, carbohydrate and other …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Inflammasomes are multimeric complexes composed of cytoplasmic sensors, apoptosis‐
associated speck‐like protein containing a caspase activation and recruitment domain (ASC …

The immune system has a central role in eliminating detrimental factors, by frequently
launching inflammatory responses towards pathogen infection and inner danger signal …

Background: The intracellular multiprotein complex termed the inflammasome functions as a
platform of pro-inflammatory cytokine production such as IL-1β and IL-18. Under certain …

The NLRP3 inflammasome is a cytosolic multiprotein caspase-activating complex platform
involved in innate immunity required for the maturation and release of interleukin (IL)-1β and …

The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in
response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory …