Metabolic dysfunction plays a key role in the development of diabetic nephropathy (DN).
However, the exact effects and mechanisms are still unclear. The pyrin domain‐containing …

Objective Inflammation is central to the development and progression of diabetic
nephropathy (DN). Although the exact mechanisms of inflammation in the kidney have not …

The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …

Tubulointerstitial inflammation plays a key role in the pathogenesis of diabetic nephropathy
(DN). Interleukin-1β (IL-1β) is the key proinflammatory cytokine associated with …

The inflammasome is a molecular platform that is created in the cytosolic compartment to
mediate the host immunological response to cellular injury and infection. Caspase-1 may be …

Cytoplasmic innate immune receptors are important therapeutic targets for diseases
associated with overproduction of proinflammatory cytokines. One cytoplasmic receptor …

Proteinuria is, not only a hallmark of glomerular disease, but also a contributor to kidney
injury. However, its pathogenic mechanism is still elusive. In the present study, the effects of …

Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide but
current treatments remain suboptimal. The role of inflammation in DN has only recently been …

Abstract Ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI) in
clinic. The activation of NLRP3 inflammasome is associated with inflammation and renal …