Tissue metabolic profiling reveals major metabolic alteration in colorectal cancer

Y Shen, M Sun, J Zhu, M Wei, H Li, P Zhao, J Wang… - Molecular omics, 2021 - pubs.rsc.org
Metabolic reprogramming is a hallmark of cancer, which is still far from being fully
understood in colorectal cancer. In order to characterize the metabolic changes in colorectal …

A distinct metabolic signature of human colorectal cancer with prognostic potential

Y Qiu, G Cai, B Zhou, D Li, A Zhao, G Xie, H Li… - Clinical cancer …, 2014 - AACR
Purpose: Metabolic phenotyping has provided important biomarker findings, which,
unfortunately, are rarely replicated across different sample sets due to the variations from …

Metabolomic comparison of patients with colorectal cancer at different anticancer treatment stages

Z Li, X Deng, J Luo, Y Lei, X Jin, J Zhu, G Lv - Frontiers in Oncology, 2022 - frontiersin.org
Background The difficulties of early diagnosis of colorectal cancer (CRC) result in a high
mortality rate. The ability to predict the response of a patient to surgical resection or …

Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis.

ES Ong, L Zou, S Li, PY Cheah, KW Eu… - Molecular & cellular …, 2010 - europepmc.org
Colorectal cancer (CRC) arises as the consequence of progressive changes from normal
epithelial cells through polyp to tumor, and thus is an useful model for studying metabolic …

Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool

DG Brown, S Rao, TL Weir, J O'Malia, M Bazan… - Cancer & …, 2016 - Springer
Background Colorectal cancers (CRC) are associated with perturbations in cellular amino
acids, nucleotides, pentose-phosphate pathway carbohydrates, and glycolytic …

Functional metabolome profiling may improve individual outcomes in colorectal cancer management implementing concepts of predictive, preventive, and …

Y Yuan, C Yang, Y Wang, M Sun, C Bi, S Sun, G Sun… - EPMA Journal, 2022 - Springer
Objectives Colorectal cancer (CRC) is one of the most common solid tumors worldwide, but
its diagnosis and treatment are limited. The objectives of our study were to compare the …

[HTML][HTML] Metabolomics for biomarker discovery in the diagnosis, prognosis, survival and recurrence of colorectal cancer: a systematic review

F Zhang, Y Zhang, W Zhao, K Deng, Z Wang, C Yang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) remains an incurable disease. There are no effective noninvasive
techniques that have achieved colorectal cancer (CRC) diagnosis, prognosis, survival and …

Metabolite profiling of human colon carcinoma–deregulation of TCA cycle and amino acid turnover

C Denkert, J Budczies, W Weichert, G Wohlgemuth… - Molecular cancer, 2008 - Springer
Background Apart from genetic alterations, development and progression of colorectal
cancer has been linked to influences from nutritional intake, hyperalimentation, and cellular …

Metabolomic markers of colorectal tumor with different clinicopathological features

Z Long, J Zhou, K Xie, Z Wu, H Yin, V Daria… - Frontiers in …, 2020 - frontiersin.org
Background: Colorectal cancer (CRC) is the result of complex interactions between the
tumor's molecular profile and metabolites produced by its microenvironment. Despite recent …

Circulating metabolites as potential biomarkers for the early detection and prognosis surveillance of gastrointestinal cancers

G Song, L Wang, J Tang, H Li, S Pang, Y Li, L Liu, J Hu - Metabolomics, 2023 - Springer
Background and aims Two of the most lethal gastrointestinal (GI) cancers, gastric cancer
(GC) and colon cancer (CC), are ranked in the top five cancers that cause deaths worldwide …