Overcoming rest–task divide—abnormal temporospatial dynamics and its cognition in schizophrenia

G Northoff, J Gomez-Pilar - Schizophrenia bulletin, 2021 - academic.oup.com
Schizophrenia is a complex psychiatric disorder exhibiting alterations in spontaneous and
task-related cerebral activity whose relation (termed “state dependence”) remains unclear …

Associative deficit accounts of disrupted latent inhibition and blocking in schizophrenia

M Escobar, P Oberling, RR Miller - Neuroscience & Biobehavioral Reviews, 2002 - Elsevier
Latent inhibition (attenuated responding to a signal due to signal-alone presentations
preceding the signal-outcome pairings) and blocking (attenuated responding to Signal B …

Frontal–striatal–thalamic mediodorsal nucleus dysfunction in schizophrenia-spectrum patients during sensorimotor gating

EA Hazlett, MS Buchsbaum, J Zhang, RE Newmark… - Neuroimage, 2008 - Elsevier
Prepulse inhibition (PPI) refers to a reduction in the amplitude of the startle eyeblink reflex to
a strong sensory stimulus, the pulse, when it is preceded shortly by a weak stimulus, the …

Neural oscillatory deficits in schizophrenia predict behavioral and neurocognitive impairments

A Martínez, PA Gaspar, SA Hillyard, S Bickel… - Frontiers in human …, 2015 - frontiersin.org
Paying attention to visual stimuli is typically accompanied by event-related
desynchronizations (ERD) of ongoing alpha (7–14 Hz) activity in visual cortex. The present …

Neural correlates of impaired cognitive control over working memory in schizophrenia

TS Eich, DE Nee, C Insel, C Malapani, EE Smith - Biological psychiatry, 2014 - Elsevier
Background One of the most common deficits in patients with schizophrenia (SZ) is in
working memory (WM), which has wide-reaching impacts across cognition. However …

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

MA Geyer, K Krebs-Thomson, DL Braff… - …, 2001 - Springer
Rationale: Patients with schizophrenia exhibit deficits in an operational measure of
sensorimotor gating: prepulse inhibition (PPI) of startle. Similar deficits in PPI are produced …

Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychotics

V Kumari, W Soni, T Sharma - Schizophrenia Research, 2002 - Elsevier
Individuals with schizophrenia are known to show deficits in prepulse inhibition (PPI) of the
startle response. PPI refers to a response suppression in reaction to a strong startling …

Reduced prepulse inhibition as a biomarker of schizophrenia

A Mena, JC Ruiz-Salas, A Puentes, I Dorado… - Frontiers in behavioral …, 2016 - frontiersin.org
The startle response is composed by a set of reflex behaviors intended to prepare the
organism to face a potentially relevant stimulus. This response can be modulated by several …

[HTML][HTML] Brain rhythms connect impaired inhibition to altered cognition in schizophrenia

BR Pittman-Polletta, B Kocsis, S Vijayan… - Biological …, 2015 - Elsevier
In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at
the level of neurobiology and on cognitive impairments at the psychological level …

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine

MR Hudson, G Rind, TJ O'brien, NC Jones - Translational psychiatry, 2016 - nature.com
Recent heuristic models of schizophrenia propose that abnormalities in the gamma
frequency cerebral oscillations may be closely tied to the pathophysiology of the disorder …