Psychiatric researchers need specific animal models to better understand the neurobiology
of schizophrenia. Prepulse inhibition (PPI), the reduction in startle produced by a prepulse …

Abstracts Prepulse inhibition (PPI) of startle is an operational measure of sensorimotor
gating that is often impaired in patients with schizophrenia. Despite the large number of …

Self-monitoring of actions, critical for guiding goal-directed behavior, is deficient in
schizophrenia. Defective error-monitoring may reflect more general self-monitoring …

Background: Schizophrenic patients suffer from cognitive and attentional deficits, particularly
from failure of executive control functions. Methods: This study investigated the cortical …

Cognitive control deficits have been consistently documented in patients with schizophrenia.
Recent work in cognitive neuroscience has hypothesized a distinction between two …

Response inhibition in schizophrenia remains controversial, with behavioral correlates
largely unknown. Inpatients with schizophrenia and controls completed a stop task and an …

BACKGROUND: Disturbances in sensorimotor gating measured by prepulse inhibition of the
startle response (PPI) have frequently been reported in medicated and unmedicated …

Schizophrenia is characterized by impaired cognitive control associated with prefrontal
cortex dysfunction, but the underlying pathophysioloical mechanisms remain unknown …

Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

Electroencephalographic (EEG) studies of auditory steady-state responses (aSSRs) non-
invasively probe gamma-band (40-Hz) oscillatory capacity in sensory cortex with high signal …