Upon fertilization, terminally differentiated gametes are transformed to a totipotent zygote,
which gives rise to an embryo. How parental epigenetic memories are inherited and …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

Epigenetic reprogramming in the germline provides a developmental model to study the
erasure of epigenetic memory as it occurs naturally in vivo in the course of normal …

Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant,
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …

Epigenetic reprogramming in the germline resets genomic potential and erases epigenetic
memory. Three studies by Gkountela et al., Guo et al., and Tang et al. analyze the …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

The term “epigenetics” has been widely used and abused (Greally, 2018) but the most
compelling definition of epigenetics is the study of changes in gene function that are …

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …