Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
Heterochronic genes form a regulatory pathway that controls the temporal sequence of the
Caenorhabditis elegans postembryonic cell lineage. One of these genes, lin-14, encodes a …
Caenorhabditis elegans postembryonic cell lineage. One of these genes, lin-14, encodes a …
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
B Wightman, TR Bürglin, J Gatto, P Arasu… - Genes & …, 1991 - genesdev.cshlp.org
The heterchronic gene lin-14 controls the temporal sequence of developmental events in the
Caenorhabditis elegans postembryonic cell lineage. It encodes a nuclear protein that …
Caenorhabditis elegans postembryonic cell lineage. It encodes a nuclear protein that …
Isoform-Specific Mutations in the Caenorhabditis elegans Heterochronic Gene lin-14 Affect Stage-Specific Patterning
BJ Reinhart, G Ruvkun - Genetics, 2001 - academic.oup.com
The Caenorhabditis elegans heterochronic gene lin-14 specifies the temporal sequence of
postembryonic developmental events. lin-14, which encodes differentially spliced LIN-14A …
postembryonic developmental events. lin-14, which encodes differentially spliced LIN-14A …
Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations …
The heterochronic gene lin-14 controls the temporal sequence of developmental events in
the C. elegans postembryonic cell lineage. It encodes a nuclear protein that is normally …
the C. elegans postembryonic cell lineage. It encodes a nuclear protein that is normally …
Structure and Function Analysis of LIN-14, a Temporal Regulator of Postembryonic Developmental Events in Caenorhabditis elegans
Y Hong, RC Lee, V Ambros - Molecular and cellular biology, 2000 - Taylor & Francis
During postembryonic development of Caenorhabditis elegans, the heterochronic gene lin-
14 controls the timing of developmental events in diverse cell types. Three alternative lin-14 …
14 controls the timing of developmental events in diverse cell types. Three alternative lin-14 …
Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.
G Ruvkun, V Ambros, A Coulson, R Waterston… - Genetics, 1989 - academic.oup.com
We describe a general strategy for the genetic mapping in parallel of multiple restriction
fragment length polymorphism (RFLP) loci. This approach allows the systematic …
fragment length polymorphism (RFLP) loci. This approach allows the systematic …
Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation
K Seggerson, L Tang, EG Moss - Developmental biology, 2002 - Elsevier
The heterochronic gene lin-28 of the nematode Caenorhabditis elegans controls the relative
timing of diverse developmental events during the animal's larval stages. lin-28 is stage …
timing of diverse developmental events during the animal's larval stages. lin-28 is stage …
The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch
G Ruvkun, J Giusto - Nature, 1989 - nature.com
During wild-type development, a protein product of the Caenorhabditis elegans
heterochronic gene lin-14 is localized to nuclei of specific somatic cells in embryos and early …
heterochronic gene lin-14 is localized to nuclei of specific somatic cells in embryos and early …
Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin‐28 in Caenorhabditis elegans
K Morita, M Han - The EMBO Journal, 2006 - embopress.org
The timing of postembryonic developmental programs in Caenorhabditis elegans is
regulated by a set of so‐called heterochronic genes, including lin‐28 that specifies second …
regulated by a set of so‐called heterochronic genes, including lin‐28 that specifies second …
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
B Wightman, I Ha, G Ruvkun - Cell, 1993 - Elsevier
During C. elegans development, the temporal pattern of many cell lineages is specified by
graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal …
graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal …
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