N-Methyl-D-aspartate (NMDA) receptor-mediated responses were studied in hippocampus,
cortex, and striatum of Fischer 344 rats of various ages (3–5, 12–14, or 24–28 months old; …

The present study was designed to determine whether the memory sparing effects of dietary
restriction during aging could be through an effect on ionotropic glutamate receptors …

Glutamatergic fast synaptic transmission is known to be altered with age in a region-specific
manner in hippocampus of memory-impaired old rats. In the present experiment, presynaptic …

Excitatory amino acids and dopamine interact to control information flow in the neostriatum.
The present study was designed to examine some of the age-induced alterations in the …

Aging is associated with reduced rates of kindling and spatial learning. Blockade of N-
methyl-D-aspartate (NMDA) receptors in young animals produces effects similar to those of …

GABA and glutamate are the most abundant neurotransmitters in the CNS and play a pivotal
part in synaptic stability/plasticity. Glutamate and GABA homeostasis is important for healthy …

We investigated regional variations and the effects of aging on the expression of the N‐
methyl‐d‐aspartate (NMDA) and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole (AMPA) …

Brain aging is related to the numerous structural and functional changes including
decreased synaptic plasticity. The beneficial effects of dietary restriction (DR) are well known …

Estrogen interacts with N-methyl-d-aspartate (NMDA) receptors to regulate multiple aspects
of morphological and functional plasticity. In the hippocampus, estrogens increase both …

The present study was designed to determine if functional age differences in the NMDA
epsilon2 (NR2B) subunit were detectable at the level of individual cortical neurons. Neurons …