Increased oxidative stress is a major contributor to the development and progression of
heart failure, however, our knowledge on the role of the distinct NADPH oxidase (NOX) …

Significance: Oxidative stress is involved in the pathogenesis of heart failure but clinical
antioxidant trials have been unsuccessful. This may be because effects of reactive oxygen …

Background/Aims: Recent studies indicate the presence of reactive oxygen species (ROS)
producing homologues of the enzymatic subunit (Nox2) of phagocytic NADPH oxidase in …

Shah Parsing the Role of Noxs in Heart Failure 603 components of the cardiac-remodeling
phenotype, including angiotensin II–induced hypertrophy (via ERK1/2, Akt, and NF-κB …

Rationale: NADPH oxidases are a major source of superoxide (O2−) in the cardiovascular
system. The function of Nox4, a member of the Nox family of NADPH oxidases, in the heart is …

NAD (P) H oxidases (Noxs) produce O2− and play an important role in cardiovascular
pathophysiology. The Nox4 isoform is expressed primarily in the mitochondria in cardiac …

Reactive oxygen species producing NADPH oxidases play important roles under different
(patho) physiological conditions. NOX1, NOX2, and NOX4 are important sources of reactive …

Abstract NADPH oxidase-4 (Nox4) is an important modulator of redox signaling that is
inducible at the level of transcriptional expression in multiple cell types. By contrast to other …

The NADPH oxidase (Nox) family of proteins is comprised of seven members, including
Noxes1–5 and the Duoxes 1 and 2. Nox4 is readily distinguished from the other Nox …

The NADPH oxidases are a key family of ROS (reactive oxygen species)-producing
enzymes which may differentially contribute to cardiac pathophysiology. Animal studies …