In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes

Y Pan, BA Abd-Rashid, Z Ismail, R Ismail… - Chemico-biological …, 2011 - Elsevier
Orthosiphon stamineus (OS) has been traditionally used to treat diabetes, kidney and
urinary disorders, high blood pressure and bone or muscular pain. To assess the possibility …

In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity

Y Pan, KH Tiong, BA Abd-Rashid, Z Ismail, R Ismail… - Phytomedicine, 2014 - Elsevier
This study was designed to investigate eight herbal active constituents (andrographolide,
asiaticoside, asiatic acid, madecassic acid, eupatorin, sinensetin, caffeic acid, and …

Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes

D Yim, MJ Kim, Y Shin, SJ Lee… - Evidence‐Based …, 2019 - Wiley Online Library
Sophora flavescens possesses several pharmacological properties and has been widely
used for the treatment of diarrhea, inflammation, abscess, dysentery, and fever in East Asian …

[HTML][HTML] Urinary metabolomics study on the protective role of Orthosiphon stamineus in Streptozotocin induced diabetes mellitus in rats via 1H NMR spectroscopy

AA Azam, R Pariyani, IS Ismail, A Ismail… - … and Alternative Medicine, 2017 - Springer
Background Orthosiphon stamineus (OS) is a herb known in ethnomedicine for treating
diabetes mellitus (DM). In this study, a 1 H NMR based urine metabolomics tool has been …

In vivo Effect of I'm-Yunity™ on Hepatic Cytochrome P450 3A4

JPA Nicandro, C Tsourounis, L Frassetto… - Journal of herbal …, 2007 - Taylor & Francis
The inhibition or induction of hepatic cytochrome P450 3A4 (CYP3A4) enzyme associated
with herbal medicines such as I'm-Yunity™(Coriolus versicolor) can result in clinically …

Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice

YF Ueng, CC Chen, CC Tsai, P Souček - Journal of ethnopharmacology, 2009 - Elsevier
AIM OF THE STUDY: Sophora flavescens has been used as an antipyretic and analgesic
agent. To assess the possible herb–drug interaction, effects of S. flavescens extracts on …

Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma

J Liu, J Chen, M Lin, F Wu, C Ma, X Zuo, W Yu… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance With the features of multiple-components and targets as
well as multifunction, traditional Chinese medicine (TCM) has been widely used in the …

Induction of hepatic cytochrome P450s by the herbal medicine Sophora flavescens extract in rats: impact on the elimination of theophylline

YF Ueng, CC Tsai, WS Lo, CH Yun - Drug Metabolism and …, 2010 - Elsevier
The roots of Sophora flavescens (Sf) have been widely used as a herbal medicine for the
treatment of diarrhea, gastrointestinal hemorrhage, and eczema. Cytochrome P450 (P450) …

Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays

Y Xing, Q Yu, L Zhou, W Cai, Y Zhang, Y Bi, Y Zhang… - Phytomedicine, 2023 - Elsevier
Abstract Background Polygonum multiflorum Thunb.(PM) is well known both in China and
other countries of the world for its tonic properties, however, it has lost its former glory due to …

Effects of Alismatis rhizome on rat cytochrome P450 enzymes

Y Huang, S Zheng, Z Xu, Y Hou - Pharmaceutical Biology, 2014 - Taylor & Francis
Abstract Context: Alismatis rhizome (RA)(Water Plantain Family, also called “Zexie” in
Chinese), one of the commonly used components of traditional Chinese medicines, is …