Although the CNS is immune privileged, continuous search for pathogens and tumours by
immune cells within the CNS is indispensable. Thus, distinct immune-cell populations also …

The migration of CD4+ effector/memory T cells across the blood–brain barrier (BBB) is a
critical step in MS or its animal model, EAE. T‐cell diapedesis across the BBB can occur …

Background Circulating memory T cells can be divided into tissue-specific subsets, which
traffic through distinct tissue compartments during physiologic immune surveillance, based …

Chemokines and their receptors may be implicated in leukocyte ingress into brain during
inflammation observed during the course of multiple sclerosis (MS). To address receptor …

The central nervous system (CNS) is classically viewed as immune-privileged; however,
recent advances highlight interactions between the peripheral immune system and CNS in …

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of
the CNS. Myelin-specific CD4+ Th lymphocytes are known to play a major role in both MS …

Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …

In chronic inflammatory diseases of the central nervous system (CNS), immune cells
persisting behind the blood-brain barrier are supposed to promulgate local tissue …

Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …

It is unclear how immune cells traffic between the lymphoid compartment and the central
nervous system (CNS), which lacks lymphatic vessels and is shielded by the blood–brain …