The adult human testis transcriptional cell atlas
Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq
Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
[HTML][HTML] The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids
Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
[HTML][HTML] The dynamic transcriptional cell atlas of testis development during human puberty
The human testis undergoes dramatic developmental and structural changes during
puberty, including proliferation and maturation of somatic niche cells, and the onset of …
puberty, including proliferation and maturation of somatic niche cells, and the onset of …
The neonatal and adult human testis defined at the single-cell level
Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis
M Wang, X Liu, G Chang, Y Chen, G An, L Yan, S Gao… - Cell stem cell, 2018 - cell.com
Spermatogenesis generates mature male gametes and is critical for the proper transmission
of genetic information between generations. However, the developmental landscapes of …
of genetic information between generations. However, the developmental landscapes of …
Decoding the spermatogenesis program: new insights from transcriptomic analyses
Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …
Chromatin and single-cell RNA-seq profiling reveal dynamic signaling and metabolic transitions during human spermatogonial stem cell development
Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and
differentiation. To understand how this is achieved, we profiled DNA methylation and open …
differentiation. To understand how this is achieved, we profiled DNA methylation and open …
[HTML][HTML] Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment
Human testis development in prenatal life involves complex changes in germline and
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
Transcription and imprinting dynamics in developing postnatal male germline stem cells
Postnatal spermatogonial stem cells (SSCs) progress through proliferative and
developmental stages to populate the testicular niche prior to productive spermatogenesis …
developmental stages to populate the testicular niche prior to productive spermatogenesis …