Immunopathogenesis of multiple sclerosis

M Comabella, SJ Khoury - Clinical immunology, 2012 - Elsevier
Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by
autoimmune inflammation, demyelination, and axonal damage. MS etiology remains …

Multiple sclerosis: prospects and promise

SL Hauser, JR Chan, JR Oksenberg - Annals of neurology, 2013 - Wiley Online Library
We have entered a golden era in multiple sclerosis (MS) research. Two decades ago, our
understanding of the disease was largely descriptive and there were no approved therapies …

The immune response in multiple sclerosis

S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …

Advances in the immunopathogenesis of multiple sclerosis

SK Yadav, JE Mindur, K Ito… - Current opinion in …, 2015 - journals.lww.com
A better understanding of immune-mediated mechanisms in the pathogenesis of multiple
sclerosis and the contribution of environmental risk factors toward the development of …

Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances

A Bar-Or, R Li - The Lancet Neurology, 2021 - thelancet.com
Novel insights from basic and translational studies are reshaping concepts of the
immunopathogenesis of multiple sclerosis and understanding of the different inflammatory …

Myeloid cells—targets of medication in multiple sclerosis

MK Mishra, VW Yong - Nature Reviews Neurology, 2016 - nature.com
Discussions of multiple sclerosis (MS) pathophysiology tend to focus on T cells and B cells
of the adaptive immune response. The innate immune system is less commonly considered …

New concepts in the immunopathogenesis of multiple sclerosis

B Hemmer, JJ Archelos, HP Hartung - Nature Reviews Neuroscience, 2002 - nature.com
Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating
neurological disease. It has been considered to be an autoimmune disorder mediated by …

[HTML][HTML] Recent advances in understanding multiple sclerosis

PK Stys, S Tsutsui - F1000Research, 2019 - ncbi.nlm.nih.gov
Emerging data point to important contributions of both autoimmune inflammation and
progressive degeneration in the pathophysiology of multiple sclerosis (MS). Unfortunately …

Inflammation in multiple sclerosis

S Haase, RA Linker - Therapeutic Advances in Neurological …, 2021 - journals.sagepub.com
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) that is characterised pathologically by demyelination, gliosis, neuro-axonal damage …

Cytokine signaling in multiple sclerosis: Lost in translation

K Göbel, T Ruck, SG Meuth - Multiple Sclerosis Journal, 2018 - journals.sagepub.com
Multiple sclerosis (MS) is a common neurological disorder of putative autoimmune origin.
Clinical studies delineate abnormal expression of specific cytokines over the course of …