A basic overview of multiple sclerosis immunopathology

N Grigoriadis, V Van Pesch - European journal of neurology, 2015 - Wiley Online Library
Multiple sclerosis (MS) is a multi‐component disease characterized by inflammation,
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …

[HTML][HTML] Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE

L Van Kaer, JL Postoak, C Wang, G Yang… - Cellular & molecular …, 2019 - nature.com
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) in which the immune system damages the protective insulation surrounding the nerve …

[HTML][HTML] CD8+ T-cells as immune regulators of multiple sclerosis

S Sinha, AW Boyden, FR Itani, MP Crawford… - Frontiers in …, 2015 - frontiersin.org
The vast majority of studies regarding the immune basis of MS (and its animal model, EAE)
have largely focused on CD4+ T-cells as mediators and regulators of disease. Interestingly …

B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases

KA McLaughlin, KW Wucherpfennig - Advances in immunology, 2008 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). The mainstream view is that MS is caused by an autoimmune attack …

Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies

P Stinissen, J Raus, J Zhang - Critical Reviews™ in …, 1997 - dl.begellhouse.com
Accumulating evidence indicates that multiple sclerosis (MS) is an autoimmune disease
mediated by autoreactive T lymphocytes with specificity for myelin antigens. Initially, the …

[HTML][HTML] Pathogenic T cell cytokines in multiple sclerosis

CA Wagner, PJ Roqué, JM Goverman - Journal of Experimental …, 2020 - rupress.org
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system that is believed to have an autoimmune etiology. As MS is the most common …

The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis

KC O'connor, A Bar-Or, DA Hafler - Journal of clinical immunology, 2001 - Springer
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system white
matter. The association of the disease with MHC genes, the inflammatory white matter …

The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis

SS Duffy, JG Lees… - Multiple sclerosis …, 2014 - Wiley Online Library
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
characterised by widespread areas of focal demyelination. Its aetiology and pathogenesis …

[HTML][HTML] The enigmatic role of viruses in multiple sclerosis: molecular mimicry or disturbed immune surveillance?

J Geginat, M Paroni, M Pagani, D Galimberti… - Trends in …, 2017 - cell.com
Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous system
(CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections promote …