Arsenic-induced epigenetic changes in cancer development

WN Saintilnord, Y Fondufe-Mittendorf - Seminars in cancer biology, 2021 - Elsevier
Arsenic is a ubiquitous metalloid whose high levels of toxicity pose major health concerns to
millions of people worldwide by increasing susceptibility to various cancers and non-cancer …

Epigenetic dysregulations in arsenic-induced carcinogenesis

R Islam, L Zhao, Y Wang, G Lu-Yao, LZ Liu - Cancers, 2022 - mdpi.com
Simple Summary Arsenic is a chemical element that is toxic, and long-term exposure to it
causes cancers such as lung, skin, liver, and bladder cancers. Over 150 million people …

Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis

M Eckstein, R Eleazer, M Rea… - Reviews on …, 2017 - degruyter.com
Arsenic is a ubiquitous metalloid that is not mutagenic but is carcinogenic. The mechanism
(s) by which arsenic causes cancer remain unknown. To date, several mechanisms have …

[HTML][HTML] Oncogenomic disruptions in arsenic-induced carcinogenesis

AP Sage, BC Minatel, KW Ng, GL Stewart… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Chronic exposure to arsenic affects more than 200 million people worldwide, and has been
associated with many adverse health effects, including cancer in several organs. There is …

Molecular mechanisms of arsenic carcinogenesis

C Huang, Q Ke, M Costa, X Shi - Molecular and cellular biochemistry, 2004 - Springer
Arsenic is a metalloid compound that is widely distributed in the environment. Human
exposure of this compound has been associated with increased cancer incidence. Although …

Epigenetic targets of arsenic: emphasis on epigenetic modifications during carcinogenesis

RV Roy, YO Son, P Pratheeshkumar… - Journal of …, 2015 - dl.begellhouse.com
ABSTRACT DNA methylation and histone modification promote opening and closure of
chromatin structure, which affects gene expression without altering the DNA sequence …

Oxidative stress, epigenetics, and cancer stem cells in arsenic carcinogenesis and prevention

L Li, F Chen - Current pharmacology reports, 2016 - Springer
The carcinogenic role of arsenic has been extensively studied for more than half century.
How arsenic causes human cancer, however, remains to be fully elucidated. In this brief …

Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis

C Yang, K Frenkel - Journal of environmental pathology …, 2002 - dl.begellhouse.com
Arsenic is a common environmental and occupational pollutant and a wellknown human
carcinogen that causes cancers in many human organs. The exact molecular mechanisms …

Arsenic and cancer: Evidence and mechanisms

RM Speer, X Zhou, LB Volk, KJ Liu… - Advances in Pharmacology, 2023 - Elsevier
Arsenic is a potent carcinogen and poses a significant health concern worldwide. Exposure
occurs through ingestion of drinking water and contaminated foods and through inhalation …

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation

JF Reichard, A Puga - Epigenomics, 2010 - Taylor & Francis
Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown
mechanisms. A growing body of evidence suggests that its carcinogenicity results from …