[HTML][HTML] Three distinct roles of aquaporin-4 in brain function revealed by knockout mice
Aquaporin-4 (AQP4) is expressed in astrocytes throughout the central nervous system,
particularly at the blood–brain and brain–cerebrospinal fluid barriers. Phenotype analysis of …
particularly at the blood–brain and brain–cerebrospinal fluid barriers. Phenotype analysis of …
New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice
Aquaporin-4 (AQP4) is the major water channel in the CNS. Its expression at fluid-tissue
barriers (blood–brain and brain–cerebrospinal fluid barriers) throughout the brain and spinal …
barriers (blood–brain and brain–cerebrospinal fluid barriers) throughout the brain and spinal …
Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling
B Yang, Z Zador, AS Verkman - Journal of Biological Chemistry, 2008 - ASBMB
Aquaporin-4 (AQP4) is a water transport protein expressed in glial cell plasma membranes,
including glial cell foot processes lining the blood-brain barrier. AQP4 deletion in mice …
including glial cell foot processes lining the blood-brain barrier. AQP4 deletion in mice …
Potential utility of aquaporin modulators for therapy of brain disorders
MC Papadopoulos, AS Verkman - Progress in brain research, 2008 - Elsevier
Of the several aquaporin (AQP) water channels expressed in the central nervous system,
AQP4 is an attractive target for drug discovery. AQP4 is expressed in astroglia, most strongly …
AQP4 is an attractive target for drug discovery. AQP4 is expressed in astroglia, most strongly …
Aquaporin-4 and brain edema
MC Papadopoulos, AS Verkman - Pediatric nephrology, 2007 - Springer
Abstract Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain,
predominantly in astrocyte foot processes at the borders between the brain parenchyma and …
predominantly in astrocyte foot processes at the borders between the brain parenchyma and …
Aquaporins: role in cerebral edema and brain water balance
The regulation of water balance in the brain is crucial. A disruption in this equilibrium causes
an increase in brain water content that significantly contributes to the pathophysiology of …
an increase in brain water content that significantly contributes to the pathophysiology of …
Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edema
ABSTRACT Aquaporin‐4 (AQP4) is the major water channel in the brain, expressed
predominantly in astroglial cell membranes. Initial studies in AQP4‐deficient mice showed …
predominantly in astroglial cell membranes. Initial studies in AQP4‐deficient mice showed …
Aquaporins in brain: distribution, physiology, and pathophysiology
J Badaut, F Lasbennes… - Journal of cerebral …, 2002 - journals.sagepub.com
Water homeostasis in the brain is of central physiologic and clinical importance. Neuronal
activity and ion water homeostasis are inextricably coupled. For example, the clearance of …
activity and ion water homeostasis are inextricably coupled. For example, the clearance of …
The aquaporin-4 water channel as a potential drug target in neurological disorders
AS Verkman, AJ Smith, P Phuan… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Aquaporin-4 (AQP4) is a water transporting protein expressed at
the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis …
the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis …
Aquaporin-4 in brain and spinal cord oedema
S Saadoun, MC Papadopoulos - Neuroscience, 2010 - Elsevier
Brain oedema is a major clinical problem produced by CNS diseases (eg stroke, brain
tumour, brain abscess) and systemic diseases that secondarily affect the CNS (eg …
tumour, brain abscess) and systemic diseases that secondarily affect the CNS (eg …