Design, synthesis, molecular docking, and molecular dynamic studies of novel quinazoline derivatives as phosphodiesterase 7 inhibitors
AA El-Malah, MM Gineinah, MT Khayat… - Frontiers in …, 2024 - frontiersin.org
Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)-specific PDE
that is expressed in immune and proinflammatory cells. In this work, we explore the …
that is expressed in immune and proinflammatory cells. In this work, we explore the …
Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors
T Castaño, H Wang, NE Campillo… - ChemMedChem …, 2009 - Wiley Online Library
PDE7 inhibitors regulate pro‐inflammatory and immune T‐cell functions, and are a
potentially novel class of drugs particularly useful for treatment of a wide variety of immune …
potentially novel class of drugs particularly useful for treatment of a wide variety of immune …
Design, Synthesis, and Structure− Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective …
Phosphodiesterase 4 catalyzes the hydrolysis of cyclic AMP and is a target for the
development of anti-inflammatory agents. We have designed and synthesized a series of …
development of anti-inflammatory agents. We have designed and synthesized a series of …
Structural optimization and bioactivity evaluation of 2-(Methylcarbonylamino) thiazole derivatives as novel PDE4B inhibitors
R Ma, N Song, X Gu, R Guo, M Shen, S Zhang, W Yang… - Tetrahedron, 2024 - Elsevier
Abstract Phosphodiesterase-4 (PDE4) is a protease belonging to the phosphodiesterase
family, with a specific function of hydrolyzing intracellular cyclic adenosine monophosphate …
family, with a specific function of hydrolyzing intracellular cyclic adenosine monophosphate …
Synthesis, docking and anti-inflammatory activity of triazole amine derivatives as potential phosphodiesterase-4 inhibitors
Background: Phosphodiesterase 4 (PDE4), is one of the members of PDE superfamily which
catalyzes the hydrolysis of cyclic adenosine monophosphate to adenosine monophosphate …
catalyzes the hydrolysis of cyclic adenosine monophosphate to adenosine monophosphate …
Design, synthesis, and pharmacological characterization of some 2‐substituted‐3‐phenyl‐quinazolin‐4(3H)‐one derivatives as phosphodiesterase inhibitors
Abstract Some 3‐phenyl‐quinazolin‐4 (3H)‐one‐2‐thioethers (3a–e, 5a, b, 7a–e, 9a–d, 10a–
d, and 12) along with 2‐aminoquinazoline derivatives 13a–c were prepared and screened …
d, and 12) along with 2‐aminoquinazoline derivatives 13a–c were prepared and screened …
Triazole‐Pyridine Dicarbonitrile Targets Phosphodiesterase 4 to Induce Cytotoxicity in Lung Carcinoma Cells
HK Keerthy, S Mohan, Basappa… - Chemistry & …, 2019 - Wiley Online Library
Abstract Phosphodiesterase 4 (PDE4) is a key enzyme involved in the hydrolysis of cyclic
adenosine monophosphate (cAMP) and widely expressed in several types of cancers. The …
adenosine monophosphate (cAMP) and widely expressed in several types of cancers. The …
A search for antiinflammatory therapies: Synthesis, in silico investigation of the mode of action, and in vitro analyses of new quinazolin‐2, 4‐dione derivatives targeting …
AH Abdelmonsef, MA Abdelhakeem… - Journal of …, 2022 - Wiley Online Library
Inflammation is the response of the body's immune system to harmful stimuli. The expression
of phosphodiesterase 4 enzyme (PDE4) was demonstrated in many inflammatory cells …
of phosphodiesterase 4 enzyme (PDE4) was demonstrated in many inflammatory cells …
Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: design, synthesis, and structure-activity relationship study of …
ZZ Zhou, BC Ge, QP Zhong, C Huang, YF Cheng… - European Journal of …, 2016 - Elsevier
In this study, catecholamides (7a–l) bearing different aromatic rings (such as pyridine-2-yl,
pyridine-3-yl, phenyl, and 2-chlorophenyl groups) were synthesized as potent …
pyridine-3-yl, phenyl, and 2-chlorophenyl groups) were synthesized as potent …
Discovery and optimization of 4-(imidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine derivatives as novel phosphodiesterase 4 inhibitors
Z Wu, F Zhang, Z Chen, X Wang, X Liu, G Yang… - Molecular Diversity, 2024 - Springer
Phosphodiesterases (PDEs) are important intracellular enzymes that hydrolyze the second
messengers cAMP and/or cGMP. Now several studies have shown that PDE4 received …
messengers cAMP and/or cGMP. Now several studies have shown that PDE4 received …