The components within cytotoxic lymphocyte granules are responsible for a significant
fraction of T and NK cell-mediated death. Perforin is stored in these granules together with …

Calreticulin is a component of cytotoxic T-lymphocyte and NK lymphocyte granules. We
report here that granule-associated calreticulin terminates with the KDEL endoplasmic …

Cytolytic T lymphocytes (CTL), natural killer cells, and lymphokine-activated killer (LAK) cells
are cytolytic cells known to release the cytolytic protein perforin and a family of proteases …

Calreticulin is an endoplasmic reticulum-resident chaperone that is stored in the cytotoxic
granules of CTLs and NK cells and is released with granzymes and perforin upon …

Perforin, a pore-forming protein secreted by cytotoxic lymphocytes, is indispensable for
destroying virus-infected cells and for maintaining immune homeostasis. Perforin …

Following its secretion from cytotoxic lymphocytes into the immune synapse, perforin binds
to target cell membranes through its Ca2+-dependent C2 domain. Membrane-bound …

The lymphocyte pore-forming protein perforin is essential for maintaining immune
homeostasis and for effective defense against intracellular pathogens. To date, there have …

Perforin is a cytolytic mediator produced by killer lymphocytes, and is stored in and released
by cytoplasmic granules. The proteh is partiall, homologous to the terminal components of …

Studies on the gene structure, on the transcript, and on perforin protein are reviewed,
including intracellular trafficking. Perforin transcription is tightly regulated and specific for …

Perforin is a secreted protein synthesized by activated cytotoxic T lymphocytes (CTL) and
natural killer (NK) cells. It is a key component of the lytic machinery of these cells, being able …