Abstract Purpose: Oncolytic adenoviruses (Ad) represent an innovative approach to cancer
therapy. Its efficacy depends on multiple actions, including direct tumor lysis and stimulation …

Purpose: Replication-selective oncolytic adenoviruses are a promising class of tumor-
targeting agents with proven safety in hundreds of patients. However, clinical responses …

Oncolytic viruses that selectively replicate in tumor cells can be used for treatment of cancer.
Accumulating data suggests that virus induced oncolysis can enhance anti-tumor immunity …

We describe receptor-targeted adeno-associated viral (AAV) vectors that allow genetic
modification of rare cell types ex vivo and in vivo while showing no detectable off-targeting …

Cancer immunotherapy targeting immune checkpoint inhibitors shows efficacy in several
human cancers, but “cold tumors” that lack immune cells are typically unresponsive. Among …

Pre-existent humoral antibody to adenovirus potentially confounds human clinical trials
involving intravascular administration of adenovirus. Using the LNCaP prostate cancer …

Abstract Background Enadenotucirev (formerly ColoAd1) is a tumor-selective chimeric
adenovirus with demonstrated preclinical activity. This phase 1 Mechanism of Action study …

Immunotherapy with tumor-infiltrating lymphocytes (TIL) or oncolytic adenoviruses, have
shown promising results in cancer treatment, when used as separate therapies. When used …

Replication-conditional, oncolytic adenoviruses are emerging as powerful tools in the
warfare on cancer. The ability to modify cell-specific infectivity or tissue-specific replication …

The stimulation of the immune system using oncolytic adenoviruses (OAds) has attracted
significant interest and several studies suggested that OAds immunogenicity might be …