We have determined the effect of various rates of glucose infusion on the rates of release of
glycerol (Ra glycerol), free fatty acids (Ra FFA), and on energy metabolism in normal human …

To examine whether hyperglycemia is an independent regulator of adipose tissue lipolysis,
we measured palmitate flux ([3H] palmitate) on two occasions in eight volunteers with insulin …

A lipolytic process in skeletal muscle has recently been demonstrated. However, the
physiological importance of this process is unknown. We investigated the role of skeletal …

Skeletal muscle contributes significantly to reduced insulin-stimulated glucose disposal in
patients with obesity and non-insulin-dependent (type II) diabetes mellitus (NIDDM). The …

We have shown that insulin controls endogenous glucose production (EGP) indirectly, via
suppression of adipocyte lipolysis. Free fatty acids (FFA) and EGP are suppressed …

To test the hypothesis that intrahepatic availability of fatty acid could modify the rate of
suppression of endogenous glucose production (EGP), acipimox or placebo was …

Context: Lipotoxicity (increased tissue fat content) has been implicated in the development
of muscle insulin resistance and type 2 diabetes mellitus (T2DM). Objective: The aim was to …

Insulin resistant glucose metabolism is a key element in the pathogenesis of Type 2 (non-
insulin-dependent) diabetes mellitus. Insulin resistance may be of both primary (genetic) …

1. Using microdialysis, we compared lipolysis, as well as the production of lactate, in human
adipose tissue and muscle after the ingestion of carbohydrate. 2. The absolute …

OBJECTIVE To characterize the ability of insulin to activate the skeletal muscle metabolic
pathways of glucose storage, oxidation, and glycolysis in normal weight patients with …