Aotearoa New Zealand Māori and Pacific Population-amplified Gout Risk Variants: CLNK Is a Separate Risk Gene at the SLC2A9 Locus

A Ji, A Shaukat, R Takei, M Bixley, M Cadzow… - The Journal of …, 2021 - jrheum.org
Objective The Māori and Pacific (Polynesian) population of Aotearoa New Zealand has a
high prevalence of gout. Our aim was to identify potentially functional missense genetic …

Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case–control sample sets

T Jin, Y Ren, X Shi, M Jiri, N He, T Feng, D Yuan… - Rheumatology …, 2015 - Springer
A genome-wide association study of gout in European populations identified 12 genetic
variants strongly associated with risk of gout, but it is unknown whether these variants are …

Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case–control sample sets

JE Hollis‐Moffatt, X Xu, N Dalbeth… - … : Official Journal of …, 2009 - Wiley Online Library
Objective To examine the role of genetic variation in the renal urate transporter SLC2A9 in
gout in New Zealand sample sets of Māori, Pacific Island, and Caucasian ancestry and to …

The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity

JE Hollis-Moffatt, PJ Gow, AA Harrison… - Arthritis research & …, 2011 - Springer
Introduction The C allele of the nonsynonymous Arg265His (rs3733591) variant of SLC2A9
confers risk for gout in Han Chinese, Solomon Island and Japanese samples, with a …

[PDF][PDF] Associations of gout with polymorphisms in SLC2A9, WDR1, CLNK, PKD2, and ABCG2 in Chinese Han and Tibetan populations

Y Zhang, K Liu, L Ma, K Liu, X Shi, Y Zhang… - Int J Clin Exp Pathol …, 2016 - e-century.us
Gout is a common inflammatory arthritis triggered by the presence of monosodium urate
(MSU) crystals in joints and connective tissues. Current evidence suggests that heredity …

Associations between SLC2A9 polymorphisms and gout susceptibility: A meta-analysis.

YH Lee, YH Seo, JH Kim, SJ Choi, JD Ji… - Zeitschrift fur …, 2017 - europepmc.org
Objective The aim of this study was to determine whether polymorphisms in solute carrier
family 2 and facilitated glucose transporter member 9 (SLC2A9) are associated with …

Integrative genome-wide association studies of eQTL and GWAS data for gout disease susceptibility

MG Lee, TC Hsu, SC Chen, YC Lee, PH Kuo… - Scientific Reports, 2019 - nature.com
There is a paucity of genome-wide association study on Han Chinese gout patients. We
performed a genome-wide association meta-analysis on two Taiwanese cohorts consisting …

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

H Matsuo, K Yamamoto, H Nakaoka… - Annals of the …, 2016 - ard.bmj.com
Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-
wide association studies (GWASs) of gout have been reported, they included self-reported …

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

A Nakayama, H Nakaoka, K Yamamoto… - Annals of the …, 2017 - ard.bmj.com
Objective A genome-wide association study (GWAS) of gout and its subtypes was performed
to identify novel gout loci, including those that are subtype-specific. Methods Putative causal …

Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study

YS Chang, CY Lin, TY Liu, CM Huang… - Arthritis Research & …, 2022 - Springer
Background Gout is a highly hereditary disease, but not all those carrying well-known risk
variants have developing gout attack even in hyperuricemia status. We performed a genome …