Objectives Molecular biological approaches have recently identified urate transporters in
renal proximal tubular cells. Human sodium-dependent phosphate cotransporter type 1 …

Gout is a common inflammatory arthritis triggered by monosodium urate deposition after
longstanding hyperuricemia. In the general community, the disease is largely polygenic in …

Objective. To explore the causal relationship between gout and Type 2 diabetes based on
genetic evidence and national outpatient database. Methods. Twenty male gout patients …

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory
arthritis. By combining data from> 140,000 individuals of European ancestry within the …

Gout is one of the most kinds of common inflammatory arthritis as a consequence of
hyperuricemia. Alpha-protein kinase 1 (ALPK1) gene locates in a gout-susceptibility locus …

We tested 16 million SNPs, identified through whole-genome sequencing of 457 Icelanders,
for association with gout and serum uric acid levels. Genotypes were imputed into 41,675 …

Background Genome-wide association studies (GWASs) have identified dozens of loci
associated with gout, but for most cases, the risk genes and the underlying molecular …

Methods: We consecutively enrolled 109 patients with gout and 102 healthy controls. The
diagnosis of gout was based on the preliminary criteria of the America College of …

Gout, which results from elevated serum uric acid (SUA), is a common form of arthritis that is
induced by urate crystals. A single nucleotide polymorphism, rs2544390, of LDL receptor …

Objective. Gout is characterized by recurrent attacks of arthritis with hyperuricaemia and
urate crystal-induced inflammation. Although urate transporters are known as risk factors …