Background Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to
identify novel genes associated with serum uric acid concentration and gout. Methods …

www. nature. com/nrrheum R esea R chhighlights 186| APRIl 2020| volume 16 In bRIef SJ Ö
gren SY ndr OM e Abatacept no better than placebo for pSS In the single-centre Abatacept …

Objective To examine whether urate‐associated genetic variants differ in their influence on
gout risk according to body mass index (BMI). Methods This research was conducted using …

We conducted a case-control study to investigate the association between 3 common
NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to …

PPM1K-DT, LOC105377323 and ADH1B genes in a genomewide association study
(GWAS) of gout using people with asymptomatic hyperuricaemia as the comparison group …

Gout is a common arthritis resulting from increased serum urate, and many loci have been
identified that are associated with serum urate and gout. However, their influence on the …

The aim of the present study was to investigate the association between genetic variants in
17 tagSNPs of the NLRP3 gene and the susceptibility to primary gouty arthritis. A genotype …

The effects of genetic variants on the interaction between hyperlipidemia and sex have not
been investigated among gout patients in Taiwan. Using Taiwan Biobank and the National …

Objective. To validate the association between genetic polymorphisms and gout in
Japanese patients, and to investigate the cumulative effects of multiple genetic factors on the …

In this study, we investigated the role of two single nucleotide polymorphisms in the
promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility …