New insights and novel therapeutic potentials for macrophages in myocardial infarction

Z Zhang, J Tang, X Cui, B Qin, J Zhang, L Zhang… - Inflammation, 2021 - Springer
Cardiovascular disease (CVD) has long been the leading cause of death worldwide, and
myocardial infarction (MI) accounts for the greatest proportion of CVD. Recent research has …

Role of macrophages in cardioprotection

J Yap, HA Cabrera-Fuentes, J Irei… - International journal of …, 2019 - mdpi.com
Cardiovascular diseases are the leading cause of mortality worldwide. It is widely known
that non-resolving inflammation results in atherosclerotic conditions, which are responsible …

[HTML][HTML] Macrophages: First guards in the prevention of cardiovascular diseases

MI Nasser, S Zhu, H Huang, M Zhao, B Wang, H Ping… - Life sciences, 2020 - Elsevier
Cardiovascular diseases (CVD) remain one of the leading causes of mortality worldwide,
especially in developing countries. It is widely known that severe inflammation can lead to …

Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction

W Zuo, R Sun, Z Ji, G Ma - Cellular & Molecular Biology Letters, 2023 - Springer
Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Cardiac macrophages and their role in ischaemic heart disease

S Frantz, M Nahrendorf - Cardiovascular research, 2014 - academic.oup.com
Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI).
Different macrophage phenotypes likely promote myocardial health vs. disease. Infarct …

Myocardial infarction: a critical role of macrophages in cardiac remodeling

T Weinberger, C Schulz - Frontiers in physiology, 2015 - frontiersin.org
Ischemic heart disease is a common condition and a leading cause of mortality and
morbidity. Macrophages, besides their role in host defense and tissue homeostasis, are …

The roles of macrophages in heart regeneration and repair after injury

Y Gao, N Qian, J Xu, Y Wang - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
Although great advances have been made, the problem of irreversible myocardium loss due
to the limited regeneration capacity of cardiomyocytes has not been fully solved. The …

Crosstalk between macrophages and cardiac cells after myocardial infarction

Y Jian, X Zhou, W Shan, C Chen, W Ge, J Cui… - Cell Communication and …, 2023 - Springer
Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death
worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing …

Macrophage heterogeneity and its impact on myocardial ischemia-reperfusion injury: an integrative review

S Xu, C Xu, J Xu, K Zhang, H Zhang - Journal of Inflammation …, 2023 - Taylor & Francis
The coronary reperfusion following acute myocardial infarction can paradoxically trigger
myocardial ischemia-reperfusion (IR) injury. This complex phenomenon involves the …

Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases

M Fernandez-Velasco, S Gonzalez-Ramos… - Biochemical …, 2014 - portlandpress.com
Emerging evidence points to the involvement of specialized cells of the immune system as
key drivers in the pathophysiology of cardiovascular diseases. Monocytes are an essential …