The inflammatory response in myocardial infarction

NG Frangogiannis, CW Smith… - Cardiovascular …, 2002 - academic.oup.com
One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

Monocytes, macrophages, and metabolic disease in atherosclerosis

MC Flynn, G Pernes, MKS Lee… - Frontiers in …, 2019 - frontiersin.org
Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease,
in which macrophages are responsible for taking up these lipids and driving disease …

[PDF][PDF] Cardiac macrophages and emerging roles for their metabolism after myocardial infarction

EB Thorp - Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Interest in cardioimmunology has reached new heights as the experimental cardiology field
works to tap the unrealized potential of immunotherapy for clinical care. Within this space is …

Targeting macrophages using nanoparticles: a potential therapeutic strategy for atherosclerosis

X Zang, M Cheng, X Zhang, X Chen - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Atherosclerosis is one of the leading causes of vascular diseases, with high morbidity and
mortality worldwide. Macrophages play a critical role in the development and local …

New insights into the immunobiology of mononuclear phagocytic cells and their relevance to the pathogenesis of cardiovascular diseases

LM Sanmarco, N Eberhardt, NE Ponce… - Frontiers in …, 2018 - frontiersin.org
Macrophages are the primary immune cells that reside within the myocardium, suggesting
that these mononuclear phagocytes are essential in the orchestration of cardiac immunity …

Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte …

M Tokutome, T Matoba, Y Nakano… - Cardiovascular …, 2019 - academic.oup.com
Aims Monocyte-mediated inflammation is a major mechanism underlying myocardial
ischaemia–reperfusion (IR) injury and the healing process after acute myocardial infarction …

Bridging innate immunity and myocardial ischemia/reperfusion injury: the search for therapeutic targets

F Arslan, DPV de Kleijn, L Timmers… - Current …, 2008 - ingentaconnect.com
Myocardial infarction necessitates new therapeutic interventions, since it still results in high
morbidity and mortality worldwide. Reperfusion therapy itself results in (acceleration of) …

Macrophages and immune cells in atherosclerosis: recent advances and novel concepts

C Cochain, A Zernecke - Basic research in cardiology, 2015 - Springer
Atherosclerotic lesion-related thrombosis is the major cause of myocardial infarction and
stroke, which together constitute the leading cause of mortality worldwide. The inflammatory …

The immune system and cardiac repair

NG Frangogiannis - Pharmacological research, 2008 - Elsevier
Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Macrophages: promising targets for the treatment of atherosclerosis

HM Wilson, RN Barker, LP Erwig - Current vascular …, 2009 - ingentaconnect.com
Atherosclerosis is now recognised as a chronic inflammatory disease occurring within the
artery wall and ultimately responsible for myocardial infarction, stroke and peripheral …