Occlusion of a coronary artery if maintained for longer period of time results in damage of the
cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself …

Macrophages play vital functions in host inflammatory reaction, tissue repair, homeostasis
and immunity. Dysfunctional macrophages have significant pathophysiological impacts on …

Acute myocardial infarction (AMI) constitutes the major cause of death in most nations and
death rates and morbidity remain substantial in the years thereafter. Inflammation is a …

Extensive necrosis of ischemic cardiomyocytes in the infarcted myocardium activates the
innate immune response triggering an intense inflammatory reaction. Release of danger …

Macrophages are essential components of the immune system and play a role in the normal
functioning of the cardiovascular system. Depending on their origin and phenotype, cardiac …

Myocardial infarction (MI) is the main cause for the progression of the left ventricle towards
congestive heart failure. The optimal healing after MI requires timely induction and …

Macrophages were first described as phagocytic immune cells responsible for maintaining
tissue homeostasis by the removal of pathogens that disturb normal function. Historically …

Cells communicate with other cells not only via direct cell–cell contact and the production of
signaling molecules but also through release of microparticles (MPs). MPs are small …

Background: Atherosclerosis is a chronic inflammatory disease and a leading cause of
coronary artery disease, peripheral vascular disease and stroke. Lipid-laden macrophages …

Myocardial infarction triggers reparative inflammatory processes programmed to repair
damaged tissue. However, often additional injury to the myocardium occurs through the …