Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific …
P Upadhyaya, BR Lindgren, SS Hecht - Drug Metabolism and Disposition, 2009 - ASPET
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
lung carcinogen in rats and may be a cause of lung cancer in smokers. NNK is metabolized …
lung carcinogen in rats and may be a cause of lung cancer in smokers. NNK is metabolized …
Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its …
P Upadhyaya, S Kalscheuer, JB Hochalter… - Chemical research in …, 2008 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in …
potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in …
Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
S Zhang, M Wang, PW Villalta… - Chemical research in …, 2009 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and
its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are potent pulmonary …
its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are potent pulmonary …
The Pyridyloxobutyl DNA Adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]guanine, Is Detected in Tissues from 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone-treated A/J Mice
NM Thomson, PM Kenney… - Chemical research in …, 2003 - ACS Publications
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
Accumulation and Persistence of DNA Adducts in Respiratory Tissue of Rats following Multiple Administrations of the Tobacco Specific Carcinogen 4-(N-Methyl-N …
SA Belinsky, CM White, JA Boucheron, FC Richardson… - Cancer Research, 1986 - AACR
(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a major nitrosamine formed in
tobacco smoke, induces a high incidence of lung, liver, and nasal cavity tumors in rats. Since …
tobacco smoke, induces a high incidence of lung, liver, and nasal cavity tumors in rats. Since …
Methyl DNA phosphate adduct formation in rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4 …
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
powerful lung carcinogen in animal models and is considered a causative factor for lung …
powerful lung carcinogen in animal models and is considered a causative factor for lung …
Analysis and identification of 2′-deoxyadenosine-derived adducts in lung and liver DNA of F-344 rats treated with the tobacco-specific carcinogen 4 …
ES Carlson, P Upadhyaya, PW Villalta… - Chemical research in …, 2018 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are carcinogenic in animal models and …
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are carcinogenic in animal models and …
Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man
E Richter, J Engl, S Friesenegger… - Chemical research in …, 2009 - ACS Publications
Exposure to the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) is considered to be an important etiological risk factor for lung cancer in …
butanone (NNK) is considered to be an important etiological risk factor for lung cancer in …
Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA
P Upadhyaya, SJ Sturla, N Tretyakova… - Chemical research in …, 2003 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a metabolite of the tobacco specific
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography− electrospray ionization …
Y Lao, PW Villalta, SJ Sturla, M Wang… - Chemical research in …, 2006 - ACS Publications
The tobacco-specific nitrosamines N '-nitrosonornicotine (NNN, 1) and 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …