Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice
AM Urban, P Upadhyaya, Q Cao… - Chemical research in …, 2012 - ACS Publications
The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a known human
carcinogen. It generates methyl and pyridyloxobutyl DNA adducts. The role of the methyl …
carcinogen. It generates methyl and pyridyloxobutyl DNA adducts. The role of the methyl …
Tissue distribution of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats
A Castonguay, H Tjalve, SS Hecht - Cancer Research, 1983 - AACR
The tissue distribution of the tobacco-specific N-nitrosamine, 4-(methylnitrosamino)-1-(3-
pyridyl)-1-butanone (NNK), in the F344 rat was studied by whole-body autoradiography and …
pyridyl)-1-butanone (NNK), in the F344 rat was studied by whole-body autoradiography and …
Comprehensive high-resolution mass spectrometric analysis of DNA phosphate adducts formed by the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3 …
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is
a potent lung carcinogen in laboratory animals and is believed to play a key role in the …
a potent lung carcinogen in laboratory animals and is believed to play a key role in the …
Metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine
SG Carmella, S Akerkar, SS Hecht - Cancer research, 1993 - AACR
Metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone, a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers …
butanone, a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers …
Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the Fischer rat
SA Belinsky, CM White, N Trushin, SS Hecht - Carcinogenesis, 1989 - academic.oup.com
The activity and distribution of the metabolic pathways of 4-(methylnitrosamino)-1-(3-pyridyl)-
1-butanone (NNK), its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol …
1-butanone (NNK), its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol …
Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat …
JR Jalas, X Ding, SE Murphy - Drug metabolism and disposition, 2003 - ASPET
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and
its carbonyl-reduction product, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are …
its carbonyl-reduction product, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are …
Dose-Response Relationship between O6-Methylguanine Formation in Clara Cells and Induction of Pulmonary Neoplasia in the Rat by 4-(Methylnitrosamino)-1-(3 …
SA Belinsky, JF Foley, CM White, MW Anderson… - Cancer research, 1990 - AACR
The relationship between the formation of O 6-methylguanine (O6MG) and the induction of
lung, liver, and nasal tumors in the Fischer 344 rat by the tobacco-specific nitrosamine 4 …
lung, liver, and nasal tumors in the Fischer 344 rat by the tobacco-specific nitrosamine 4 …
Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats
E Richter, AR Tricker - Carcinogenesis, 1994 - academic.oup.com
The effect of nicotine on the metabolism of the tobacco-specific nitrosamine 4-
(methylnitrosamlno)-1-(3-pyridyl)-1-butanone (NNK) was studied in rats.[1-14C] NNK was sc …
(methylnitrosamlno)-1-(3-pyridyl)-1-butanone (NNK) was studied in rats.[1-14C] NNK was sc …
A/J mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates
SS Hecht, MA Morse, KI Eklind… - Experimental lung …, 1991 - Taylor & Francis
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an important carcinogen found in
tobacco and tobacco smoke. It is a potent lung tumorigen in rodents and appears to be …
tobacco and tobacco smoke. It is a potent lung tumorigen in rodents and appears to be …
Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) …
L Li, V Megaraj, Y Wei, X Ding - Carcinogenesis, 2014 - academic.oup.com
Abstract Cytochrome P450 (P450) enzymes encoded by the mouse Cyp2abfgs gene cluster
are preferentially expressed in the respiratory tract. Previous studies have demonstrated that …
are preferentially expressed in the respiratory tract. Previous studies have demonstrated that …