The effect of tobacco smoke, nicotine, and cotinine on the mutagenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
B Brown, J Avalos, C Lee, D Doolittle - Mutation Research/Genetic …, 2001 - Elsevier
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a rodent carcinogen that is
metabolically derived from carbonyl reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
metabolically derived from carbonyl reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J …
BG Brown, E Richter, AR Tricker, PH Ayres… - Chemico-biological …, 2001 - Elsevier
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine,
induces lung adenomas in A/J mice following a single intraperitoneal (ip) injection …
induces lung adenomas in A/J mice following a single intraperitoneal (ip) injection …
Mutagenesis by O6-[4-Oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and Human Cells
GT Pauly, LA Peterson, RC Moschel - Chemical research in …, 2002 - ACS Publications
Site-specific mutagenesis by O 6-[4-oxo-4-(3-pyridyl) butyl] guanine (O 6-pobGua), a product
of DNA pyridyloxobutylation by metabolites of the tobacco-specific nitrosamines N …
of DNA pyridyloxobutylation by metabolites of the tobacco-specific nitrosamines N …
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells
TJ Smith, Z Guo, FJ Gonzalez, FP Guengerich… - Cancer research, 1992 - AACR
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent tobacco-specific carcinogen in
animals, has been linked to tobacco-related cancers in humans. The cytochrome (s) P-450 …
animals, has been linked to tobacco-related cancers in humans. The cytochrome (s) P-450 …
Effects of deuterium substitution on the tumorigenicity of 4-(metlhylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice
SS Hecht, KG Jordan, CI Choi, N Trushin - Carcinogenesis, 1990 - academic.oup.com
Bioassays and DNA-binding studies of 4-(methylnitros-amino)-1-(3-pyridyl)-1-butanone
(NNK) and its analogs with deuterium substitution at the positions α to the nitrosamino group …
(NNK) and its analogs with deuterium substitution at the positions α to the nitrosamino group …
Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N′-Nitrosonornicotine Metabolism
The International Agency for Research on Cancer has classified the tobacco-specific
nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides
TJ Smith, GD Stoner, CS Yang - Cancer research, 1995 - AACR
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent tobacco-specific carcinogen,
has been demonstrated to induce lung tumors in animals and is suspected to be a human …
has been demonstrated to induce lung tumors in animals and is suspected to be a human …
Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers.
JP Richie Jr, SG Carmella, JE Muscat, DG Scott… - … , biomarkers & prevention …, 1997 - AACR
Incidence and mortality rates for lung cancer in the United States are significantly greater in
blacks than in whites. This disparity cannot be explained by differences in smoking behavior …
blacks than in whites. This disparity cannot be explained by differences in smoking behavior …
Identification of an N′-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA
Y Li, SS Hecht - Chemical research in toxicology, 2021 - ACS Publications
The tobacco-specific nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) are considered to be two of the most important carcinogens …
1-(3-pyridyl)-1-butanone (NNK) are considered to be two of the most important carcinogens …
Molecular Dosimetry of DNA Adduct Formation and Cell Toxicity in Rat Nasal Mucosa following Exposure to the Tobacco Specific Nitrosamine 4-(N-Methyl-N …
SA Belinsky, VE Walker, RR Maronpot, JA Swenberg… - Cancer research, 1987 - AACR
The molecular dosimetry of O 6-methylguanine (O6MG) formation in DNA and cytotoxicity in
respiratory and olfactory mucosa was determined during administration of 4-(N-methyl-N …
respiratory and olfactory mucosa was determined during administration of 4-(N-methyl-N …