Background CXC motif chemokine 12 (CXCL12) is a chemokine that performs many
functions. Studies have shown that CXCL12 can aggravate inflammatory symptoms in the …

T-cell accumulation in the central nervous system (CNS) is considered crucial to the
pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the …

The approximately 50 known chemokines are classified in distinct subfamilies: CXC, CC,
CX3C, and C. Although the signaling of chemokines often is promiscuous, signaling events …

Intracerebral infection of mice with mouse hepatitis virus (MHV) results in an acute
encephalomyelitis followed by a chronic demyelinating disease with clinical and histological …

The chemokine, CXC motif ligand 13 (CXCL13), is constitutively expressed in lymphoid
organs and controls the recruitment and compartmentalization of lymphocytes and antigen …

The chemokines CXCL9 and CXCL10 bind to the common receptor CXCR3 and are
implicated in the pathogenesis of T‐cell‐mediated immunity in the central nervous system …

Multiple sclerosis (MS) is an autoimmune disease of the CNS characterized by disruption of
the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred …

The chemokine CXCL10 is expressed in the central nervous system (CNS) during
neuroinflammatory conditions. Neurons express CXCR3, the receptor for CXCL10, and …

Multiple sclerosis (MS) is characterized by pathological inflammation that results from the
recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to …

Background: Neurological diseases have become an obvious challenge due to insufficient
therapeutic intervention. Therefore, novel drugs for various neurological disorders are in …