The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage
degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are …

Recent investigations into the striking heterogeneity of cellular reaction patterns that are
characteristic for, and puzzling in, osteoarthritic cartilage degeneration addressed apoptotic …

Aging is a natural process by which every single living organism approaches its twilight of
existence in a natural way. However, aging is also linked to the pathogenesis of a number of …

Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

This review focuses on recent findings in pathobiology of osteoarthritis (OA). The progress in
this field will be illustrated based on three questions; 1. What factors maintain or alter the …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …

Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the
adult population. OA is primarily caused by trauma induced by an external force or by age …

Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …

Osteoarthritis (OA) is a disease of high ethical and economical importance. In advanced
stages, the patients suffer from severe pain and restriction of mobility. The consequence in …