Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later
disease-risk in the offspring. The placenta, interposed between the mother and the foetus, is …

Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy
outcomes. It is known that GDM is associated with an altered placental function and changes …

Diabetes in pregnancy is associated with adverse pregnancy outcomes and poses a serious
threat to the health of mother and child. Although the pathophysiological mechanisms that …

Aims/Hypothesis We hypothesized that diabetes during pregnancy (DDP) alters genome-
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …

Emerging evidences indicate that placenta plays a critical role in gestational diabetes
mellitus (GDM). DNA methylation could be associated with altered placental development …

In this study, we investigated the association between altered methylation in the maternal
placenta and hyperglycaemia and explored the epigenetic mechanisms underlying …

Intrauterine exposure to hyperglycemia is reported to confer increased metabolic risk in later
life, supporting the 'developmental origins of health and disease'hypothesis. Epigenetic …

Maternal hyperglycemia during pregnancy is associated with excess fetal growth and
adverse perinatal and developmental outcomes. Placental epigenetic maladaptation may …

Background In utero exposure to diabetes has been shown to contribute to preterm birth,
though the underlying biological mechanisms are yet to be fully elucidated. Fetal epigenetic …

The placenta participates in maternal insulin sensitivity changes during pregnancy;
however, mechanisms remain unclear. We investigated associations between maternal …