Inflammatory diseases are a major burden on humanity, despite recent successes with
biopharmaceuticals. Lack of responsiveness and resistance to these drugs, delivery …

Abstract This 'state-of-the-art'review specifically focuses on alternative signalling pathways
deeply involved in acute and chronic inflammatory responses initiated by various …

Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …

Inflammatory and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel
diseases, multiple sclerosis, psoriasis and asthma, provide drug discoverers with a …

Inflammation is an evolutionarily conserved host reaction that is initiated in response to
trauma, tissue damage and infection. It leads to changes in tissue homeostasis and blood …

Many chronic inflammatory diseases are associated with deregulated intracellular signal
transduction pathways. Resultant pathogenic interactions between immune and stromal …

Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

Pro-inflammatory signaling: Last pieces in the NF-kB puzzle? Page 1 Dispatch R19 Pro-inflammatory
signaling: Last pieces in the NF-kB puzzle? Patrick A. Baeuerle The discovery of three …

Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is
responsible for eradicating invading microorganisms through the induction of inflammatory …