Physiological underpinnings of exertional dyspnoea in mild fibrosing interstitial lung disease

RM Smyth, JA Neder, MD James, SG Vincent… - Respiratory Physiology …, 2023 - Elsevier
The functional disturbances driving “out-of-proportion” dyspnoea in patients with fibrosing
interstitial lung disease (f-ILD) showing only mild restrictive abnormalities remain poorly …

Qualitative dimensions of exertional dyspnea in fibrotic interstitial lung disease

MR Schaeffer, JA Guenette, AH Ramsook… - Respiratory Physiology …, 2019 - Elsevier
Unsatisfied inspiration is commonly reported during exercise by patients with interstitial lung
disease (ILD). However, the physiological basis of perceived dyspnea quality in this …

Systemic Determinants of Exercise Intolerance in Patients With Fibrotic Interstitial Lung Disease and Severely Impaired DLCO

RM Smyth, MD James, SG Vincent, KM Milne… - Respiratory …, 2023 - rc.rcjournal.com
BACKGROUND: The precise mechanisms driving poor exercise tolerance in patients with
fibrotic interstitial lung diseases (fibrotic ILDs) showing a severe impairment in single-breath …

Physiological predictors of exertional oxygen desaturation in patients with fibrotic interstitial lung disease

V Alfieri, E Crisafulli, D Visca, WH Chong… - European …, 2020 - Eur Respiratory Soc
In patients with fibrotic interstitial lung disease (ILD), hypoxaemia on exertion is frequent,
and contributes to exercise intolerance, exertional dyspnoea and reduced quality of life [1 …

Neurophysiological mechanisms of exertional dyspnoea in fibrotic interstitial lung disease

MR Schaeffer, CJ Ryerson… - European …, 2018 - Eur Respiratory Soc
Our understanding of the mechanisms of dyspnoea in fibrotic interstitial lung disease (ILD) is
incomplete. The aims of this study were two-fold: 1) to determine whether dyspnoea intensity …

Review series: Aspects of interstitial lung disease: Exercise limitation in interstitial lung disease-mechanisms, significance and therapeutic options

AE Holland - Chronic Respiratory Disease, 2010 - journals.sagepub.com
Exercise limitation is a cardinal feature of the interstitial lung diseases and is frequently
associated with marked dyspnoea on exertion. People with interstitial lung disease exhibit a …

Uncovering the mechanisms of exertional dyspnoea in combined pulmonary fibrosis and emphysema

CM Costa, JA Neder, CG Verrastro… - European …, 2020 - Eur Respiratory Soc
The prevailing view is that exertional dyspnoea in patients with combined idiopathic
pulmonary fibrosis (IPF) and emphysema (CPFE) can be largely explained by severe …

Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study

SA Guler, SA Hur, SA Lear, PG Camp, CJ Ryerson - Respiratory research, 2019 - Springer
Background Patients with fibrotic interstitial lung disease (ILD) are frequently physically
inactive and many ILD subtypes are characterized by risk factors for myopathy; however, the …

[PDF][PDF] Exercise limitation in interstitial lung disease-mechanisms, significance and therapeutic options

AE Holland - Chron Respir Dis, 2010 - Citeseer
Exercise limitation is a cardinal feature of the interstitial lung diseases and is frequently
associated with marked dyspnoea on exertion. People with interstitial lung disease exhibit a …

Qualitative aspects of exertional dyspnea in patients with interstitial lung disease

DE O'Donnell, LKL Chau… - Journal of Applied …, 1998 - journals.physiology.org
We compared qualitative and quantitative aspects of perceived exertional dyspnea in
patients with interstitial lung disease (ILD) and normal subjects and sought a physiological …