To date, 12 members of the human ABCA subfamily are identified. They share a high degree
of sequence conservation and have been mostly related with lipid trafficking in a wide range …

Apolipoprotein E (apoE) produced by macrophages in the arterial wall protects against
atherosclerosis, but the regulation of its secretion by these cells is poorly understood. Here …

Initial lipidation of apoA-I by hepatic ABCA1 is critical for plasma HDL formation because it
enables pre-β HDL to function more efficiently as a cholesterol acceptor for other pathways …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol
transport pathway by mediating lipid efflux from macrophages. Previously, it was …

The process of cholesterol absorption has yet to be completely defined at the molecular
level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons …

The maintenance of cellular cholesterol homeostasis is essential for normal cell function and
viability. Excessive cholesterol accumulation is detrimental to cells and serves as the …

Cholesterol is a major component of mammalian cell membranes and plays important
structural and functional roles. However, excessive cholesterol accumulation is toxic to cells …

ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the
central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein …

We have investigated whether a raft heterogeneity exists in human monocyte‐derived
macrophages and fibroblasts and whether these microdomains are modulated by lipid …