Identification of a high affinity binding site for abscisic acid on human lanthionine synthetase component C-like protein 2

E Cichero, C Fresia, L Guida, V Booz, E Millo… - The international journal …, 2018 - Elsevier
Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the
mammalian receptor mediating the functional effects of the universal stress hormone …

Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics

P Lu, DR Bevan, SN Lewis, R Hontecillas… - Journal of molecular …, 2011 - Springer
The rates of type 2 diabetes (T2D) are rising to epidemic proportions in the US and
worldwide. While current T2D medications are efficacious, significant side effects have …

Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes

P Lu, R Hontecillas, CW Philipson… - Current drug …, 2014 - ingentaconnect.com
Lanthionine synthetase component C-like protein 2 (LANCL2) is a member of the LANCL
protein family, which is broadly expressed throughout the body. LANCL2 is the molecular …

[HTML][HTML] LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway

S Spinelli, G Begani, L Guida, M Magnone… - Molecular …, 2021 - Elsevier
Objective Abscisic acid (ABA) is a plant hormone also present and active in animals. In
mammals, ABA regulates blood glucose levels by stimulating insulin-independent glucose …

Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo

L Sturla, E Mannino, S Scarfì, S Bruzzone… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Abscisic acid (ABA) is a plant hormone also present in animals, where it is involved in the
regulation of innate immune cell function and of glucose disposal, through its receptor …

[HTML][HTML] G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2

C Fresia, T Vigliarolo, L Guida, V Booz, S Bruzzone… - Scientific reports, 2016 - nature.com
Abscisic acid (ABA), a long known phytohormone, has been recently demonstrated to be
present also in humans, where it targets cells of the innate immune response, mesenchymal …

[HTML][HTML] The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure

S Spinelli, V Cossu, M Passalacqua… - International Journal of …, 2023 - mdpi.com
The abscisic acid (ABA)/LANC-like protein 1/2 (LANCL1/2) hormone/receptor system
regulates glucose uptake and oxidation, mitochondrial respiration, and proton gradient …

Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family

H Mayer, M Pongratz, R Prohaska - DNA Sequence, 2001 - Taylor & Francis
We identified and characterized the cDNA coding for human LANCL2, a new member of the
eukaryotic LanC-like protein family which is related to the bacterial lanthionine synthetase …

[HTML][HTML] Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle

A Leber, R Hontecillas, N Tubau-Juni… - Scientific Reports, 2020 - nature.com
Abscisic acid is a phytohormone found in fruits and vegetables and is endogenously
produced in mammals. In humans and mice, lanthionine synthetase C-like 2 (LANCL2) has …

[HTML][HTML] Abscisic acid: A conserved hormone in plants and humans and a promising aid to combat prediabetes and the metabolic syndrome

M Magnone, L Sturla, L Guida, S Spinelli, G Begani… - Nutrients, 2020 - mdpi.com
Abscisic acid (ABA) is a hormone with a very long evolutionary history, dating back to the
earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely the …