Following the involvement of CHCHD10 in FrontoTemporal-Dementia-Amyotrophic Lateral
Sclerosis (FTD-ALS) clinical spectrum, a founder mutation (p. Gly66Val) in the same gene …

Although multiple CHCHD10 mutations are associated with the spectrum of familial and
sporadic frontotemporal dementia–amyotrophic lateral sclerosis (FTD–ALS) diseases …

Mutations in CHCHD10, a gene coding for a mitochondrial intermembrane space protein,
are associated with Frontotemporal dementia (FTD)-Amyotrophic lateral sclerosis (ALS) …

CHCHD2 mutations have been identified in various neurological diseases such as
Parkinson's disease (PD), frontotemporal dementia (FTD), and Alzheimer's disease (AD). It …

Abstract Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a
mitochondrial protein that plays important roles in cristae structure, oxidative …

Mutations in paralogous mitochondrial proteins CHCHD2 and CHCHD10 cause autosomal
dominant Parkinson Disease (PD) and Amyotrophic Lateral Sclerosis/Frontotemporal …

Objectives Mutations in the CHCHD 10 gene, which encodes a mitochondrially targeted
protein, have emerged as an important cause of motor neuron disease and frontotemporal …

Sir, In 2014, we provided a genetic basis to support the conclusion that mitochondrial
dysfunction can have a causative effect in motor neuron degeneration. We reported a large …

Recently, we provided genetic basis showing that mitochondrial dysfunction can trigger
motor neuron degeneration, through identification of CHCHD10 encoding a mitochondrial …

Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among
which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are …