The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's
research team made many efforts on revealing the oncogenic function of hypoxic inducible …

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …

Purpose: Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …

Background Pancreatic cancer is a devastating disease that is characterized by persistent
hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …

Background and aims Pancreatic cancer is characterized by inadequate vascularization and
considerable tumor hypoxia is prevalent. However, whether hypoxia-inducible factor 1α (HIF …

Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …

Background: Early diagnosis in pancreatic cancer is key for improving prognosis. Hypoxia
plays a critical role in tumor progression. Thus, an evaluation of associations between …

Hypoxia contributes to pancreatic cancer progression and promotes its growth and invasion.
Previous research principally focused on hypoxia-inducible factor-1 alpha (HIF-1α) and HIF …