[HTML][HTML] Recent advances in understanding the role of glucagon-like peptide 1

J Reed, SC Bain, V Kanamarlapudi - F1000Research, 2020 - ncbi.nlm.nih.gov
The discovery that glucagon-like peptide 1 (GLP-1) mediates a significant proportion of the
incretin effect during the postprandial period and the subsequent observation that GLP-1 …

Glucagon-like peptide-1: glucose homeostasis and beyond

YM Cho, Y Fujita, TJ Kieffer - Annual review of physiology, 2014 - annualreviews.org
Glucagon-like peptide-1 (GLP-1), an incretin hormone secreted primarily from the intestinal
L-cells in response to meals, modulates nutrient homeostasis via actions exerted in multiple …

GLP‐1: physiological effects and potential therapeutic applications

K Aaboe, T Krarup, S Madsbad… - Diabetes, Obesity and …, 2008 - Wiley Online Library
Glucagon‐like peptide 1 (GLP‐1) is a gut‐derived incretin hormone with the potential to
change diabetes. The physiological effects of GLP‐1 are multiple, and many seem to …

Therapeutic strategies based on glucagon-like peptide 1

CF Deacon - Diabetes, 2004 - Am Diabetes Assoc
Glucagon-like peptide (GLP)-1 is an incretin hormone with potent glucose-dependent
insulinotropic and glucagonostatic actions, trophic effects on the pancreatic β-cells, and …

GLP-1 agonist-based therapies: an emerging new class of antidiabetic drug with potential cardioprotective effects

M Sulistio, C Carothers, M Mangat, M Lujan… - Current atherosclerosis …, 2009 - Springer
Cardiovascular disease is a leading cause of death in the United States and across the
world, and better therapies are constantly being sought to improve patient outcomes. Recent …

Glucagon-like peptide-1, glucose homeostasis and diabetes

JJ Holst, CF Deacon, T Vilsbøll, T Krarup… - Trends in molecular …, 2008 - cell.com
Incretins, enhancers of insulin secretion, are essential for glucose tolerance, and a reduction
in their function might contribute to poor β-cell function in patients with type-2 diabetes …

Glucagon-like peptide 1 in health and disease

A Andersen, A Lund, FK Knop, T Vilsbøll - Nature Reviews …, 2018 - nature.com
In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates
insulin release and suppresses glucagon secretion in response to the ingestion of nutrients …

GLP-1 based therapies: clinical implications for gastroenterologists

MM Smits, DH van Raalte, L Tonneijck, MHA Muskiet… - Gut, 2016 - gut.bmj.com
The gut-derived incretin hormone, glucagon-like peptide 1 (GLP-1) lowers postprandial
blood glucose levels by stimulating insulin and inhibiting glucagon secretion. Two novel …

Glucagon‐like peptide‐1‐based therapies and cardiovascular disease: looking beyond glycaemic control

P Anagnostis, VG Athyros, F Adamidou… - Diabetes, Obesity …, 2011 - Wiley Online Library
Type 2 diabetes mellitus is a well‐established risk factor for cardiovascular disease (CVD).
New therapeutic approaches have been developed recently based on the incretin …

Minireview: update on incretin biology: focus on glucagon-like peptide-1

PL Brubaker - Endocrinology, 2010 - academic.oup.com
The incretin hormone, glucagon-like peptide-1 (GLP-1), is now being used in the clinic to
enhance insulin secretion and reduce body weight in patients with type 2 diabetes. Although …