Genome-wide analysis of the indispensable role of non-structural proteins in the replication of sars-cov-2

Y Jin, M Ouyang, T Yu, J Zhuang, W Wang… - Frontiers in …, 2022 - frontiersin.org
Understanding the process of replication and transcription of SARS-CoV-2 is essential for
antiviral strategy development. The replicase polyprotein is indispensable for viral …

Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Y Jiang, K Tong, R Yao, Y Zhou, H Lin, L Du, Y Jin… - Cell & Bioscience, 2021 - Springer
Background Analysis of viral protein–protein interactions is an essential step to uncover the
viral protein functions and the molecular mechanism for the assembly of a viral protein …

Expression profile and localization of SARS-CoV-2 nonstructural replicase proteins in infected cells

FS Shi, Y Yu, YL Li, L Cui, Z Zhao, M Wang… - Microbiology …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is responsible for the COVID-
19 pandemic that has caused unprecedented loss of life and economic trouble all over the …

Fidelity of ribonucleotide incorporation by the SARS-CoV-2 replication complex

X Yin, H Popa, A Stapon, E Bouda… - Journal of Molecular …, 2023 - Elsevier
The SARS-CoV-2 coronavirus has caused a global pandemic. Despite the initial success of
vaccines at preventing infection, genomic variation has led to the proliferation of variants …

Nonstructural protein 7 and 8 complexes of SARS‐CoV‐2

C Zhang, L Li, J He, C Chen, D Su - Protein Science, 2021 - Wiley Online Library
The pandemic outbreak of coronavirus disease 2019 (COVID‐19) across the world has led
to millions of infection cases and caused a global public health crisis. Current research …

Eight-amino-acid sequence at the N-terminus of SARS-CoV-2 nsp1 is involved in stabilizing viral genome replication

S Ueno, S Amarbayasgalan, Y Sugiura, T Takahashi… - Virology, 2024 - Elsevier
Coronavirus disease 19 is caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) enveloped virus with a single-stranded positive-sense ribonucleic acid …

Bio-Chemoinformatics-Driven Analysis of nsp7 and nsp8 Mutations and Their Effects on Viral Replication Protein Complex Stability

BJJ Subong, T Ozawa - Current Issues in Molecular Biology, 2024 - mdpi.com
The nonstructural proteins 7 and 8 (nsp7 and nsp8) of SARS-CoV-2 are highly important
proteins involved in the RNA-dependent polymerase (RdRp) protein replication complex. In …

[HTML][HTML] Genomic diversity of SARS-CoV-2 can be accelerated by mutations in the nsp14 gene

K Takada, MT Ueda, S Shichinohe, Y Kida, C Ono… - Iscience, 2023 - cell.com
Coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
encode a proofreading exonuclease, nonstructural protein 14 (nsp14), that helps ensure …

Identification of a membrane-associated element (MAE) in the C-terminal region of SARS-CoV-2 nsp6 that is essential for viral replication

Y Han, Z Yuan, Z Yi - Journal of Virology, 2024 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel
coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has …

A SARS-CoV-2 mini-genome assay based on negative-sense RNA to study replication inhibitors and emerging mutations

T Vial, MS Oade, CA Russell, D Eggink… - BioRxiv, 2021 - biorxiv.org
Abstract Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) is a positive-sense single-
stranded RNA virus and the causative agent of the Coronavirus disease 2019 (COVID-19) …