The endoplasmic reticulum (ER) is a multifunctional organelle critical for the proper folding
and assembly of secreted and transmembrane proteins. Perturbations of ER functions cause …

The endoplasmic reticulum (ER) is a multifunctional organelle within which protein folding,
lipid biosynthesis, and calcium storage occurs. Perturbations such as energy or nutrient …

Senescence is a complex cellular state, which can be considered as a stress response
phenotype. However, the mechanisms through which cells acquire and maintain this …

Multiple factors lead to proteostatic perturbations, often resulting in the aberrant
accumulation of toxic misfolded proteins. Cells, from yeast to humans, can respond to …

The endoplasmic reticulum (ER) is a multifunctional organelle which co-ordinates protein
folding, lipid biosynthesis, calcium storage and release. Perturbations that disrupt ER …

The aging process is characterized by a progressive decline in the function of most tissues,
representing the main risk factor in the development of a variety of human diseases. Studies …

The aging process is characterized by tissue decline and the onset of age-associated
disease. It is not, however, immutable, and aging can be modulated by various genetic and …

The endoplasmic reticulum (ER) is the principal cellular organelle in which correct folding
and maturation of transmembrane, secretory, and ER-resident proteins occur. Research …

The importance of proteostasis in preventing cellular senescence has been well recognized.
However, the exact mechanism by which the loss of proteostasis or endoplasmic reticulum …

Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein
homeostasis (proteostasis), resulting in protein misfolding and aggregation. To sense and …