Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells

D Blöcker, K Pohlmann, G Haug, C Bachmeyer… - Journal of Biological …, 2003 - ASBMB
The binary Clostridium botulinum C2 toxin consists of two individual proteins, the transport
component C2II (80 kDa) and the enzyme component C2I, which ADP-ribosylates G-actin in …

The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components

H Barth, R Roebling, M Fritz, K Aktories - Journal of Biological Chemistry, 2002 - ASBMB
The binary Clostridium botulinum C2 toxin is composed of the enzyme component C2I and
the binding component C2II, which are individual and non-linked proteins. Activated C2IIa …

Purification of TAT‐C3 exoenzyme

E Sahai, MF Olson - Methods in enzymology, 2006 - Elsevier
The Clostridium botulinum C3 exoenzyme has been an invaluable tool for the study of the
biological functions of Rho GTPases. The C3 enzyme selectively catalyzes the ADP …

Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

H Barth, D Blöcker, J Behlke… - Journal of Biological …, 2000 - ASBMB
The actin-ADP-ribosylating binaryClostridium botulinum C2 toxin consists of two individual
proteins, the binding/translocation component C2II and the enzyme component C2I. To elicit …

Comparative analysis of C3 and botulinal neurotoxin genes and their environment in Clostridium botulinum types C and D

D Hauser, M Gibert, MW Eklund, P Boquet… - Journal of …, 1993 - Am Soc Microbiol
The C3 exoenzyme gene is located on a bacteriophage in Clostridium botulinum types C
and D (MR Popoff, D. Hauser, P. Boquet, MW Eklund, and DM Gill, Infect. Immun. 59: 3673 …

[引用][C] Signalling by Rho family proteins

AJ Ridley - Biochemical Society Transactions, 1997 - portlandpress.com
The Rho family is part of the Ras superfamily of small GTP-binding proteins, and consists of
Rho (A, B and C), Rac (1 and 2), two Cdc42 isoforms, RhoD, RhoE, RhoG, TClO and TTF [l] …

C3 Rho-inhibitor for targeted pharmacological manipulation of osteoclast-like cells

A Tautzenberger, C Förtsch, C Zwerger, L Dmochewitz… - PloS one, 2013 - journals.plos.org
The C3 toxins from Clostridium botulinum (C3bot) and Clostridium limosum (C3lim) as well
as C3-derived fusion proteins are selectively taken up into the cytosol of monocytes …

The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes

J Eisele, S Schreiner, J Borho, S Fischer… - Frontiers in …, 2022 - frontiersin.org
The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the
enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects …

Clostridium botulinum C3 ADP-Ribosyltransferase

K Aktories, C Mohr, G Koch - ADP-Ribosylating Toxins, 1992 - Springer
During the last few years various clostridial ADP-ribosylating exoenzymes have been
described. These exoenzymes can be divided into two groups. One group is represented …

Structure, function and evolution of Clostridium botulinum C2 and C3 toxins: Insight to poultry and veterinary vaccines

P Chellapandi, A Prisilla - Current Protein and Peptide Science, 2017 - ingentaconnect.com
Clostridium botulinum group III strains are able to produce cytotoxins, C2 toxin and C3
exotoxin, along with botulinum neurotoxin types C and D. C2 toxin and C3 exotoxin …