Cellular Uptake of Clostridium botulinum C2 Toxin: Membrane Translocation of a Fusion Toxin Requires Unfolding of Its Dihydrofolate Reductase Domain
G Haug, C Wilde, J Leemhuis, DK Meyer, K Aktories… - Biochemistry, 2003 - ACS Publications
The Clostridium botulinum C2 toxin is the prototype of the family of binary actin− ADP-
ribosylating toxins. C2 toxin is composed of two separated nonlinked proteins. The enzyme …
ribosylating toxins. C2 toxin is composed of two separated nonlinked proteins. The enzyme …
Morphological effects, rate of incorporation, and the enzymatic action of botulinum ADP‐ribosyltransferase, known as C3 exoenzyme, on human neuroblastoma GOTO …
Y Kamata, T Nishiki, K Matsumura… - Microbiology and …, 1994 - Wiley Online Library
The susceptibility of various lines of cultured cells to botulinum ADP‐ribosyltransferase,
known as C3 exoenzyme, was examined. Human neuroblastoma GOTO cells were most …
known as C3 exoenzyme, was examined. Human neuroblastoma GOTO cells were most …
Channel Formation by the Binding Component of Clostridium botulinum C2 Toxin: Glutamate 307 of C2II Affects Channel Properties in Vitro and pH-Dependent C2I …
D Blöcker, C Bachmeyer, R Benz, K Aktories… - Biochemistry, 2003 - ACS Publications
The binding component (C2II) of the binary Clostridium botulinum C2 toxin mediates
transport of the actin ADP-ribosylating enzyme component (C2I) into the cytosol of target …
transport of the actin ADP-ribosylating enzyme component (C2I) into the cytosol of target …
Clostridium botulinum C2 toxin: binding studies with fluorescence-activated cytometry
BG Stiles, D Blöcker, ML Hale, MA Guetthoff, H Barth - Toxicon, 2002 - Elsevier
Clostridium botulinum C2 enterotoxin consists of two unlinked proteins designated as C2II,
which recognizes a cell-surface glycoprotein and translocates an ADP-ribosyltransferase …
which recognizes a cell-surface glycoprotein and translocates an ADP-ribosyltransferase …
Differentiation‐induced increase in Clostridium botulinum C3 exoenzyme‐catalyzed ADP‐ribosylation of the small GTP‐binding protein Rho
G Fritz, I Just, P Wollenberg… - European journal of …, 1994 - Wiley Online Library
The specific [32P] ADP‐ribosylation by Clostridium botulinum exoenzyme C3 was used to
study differentiation‐dependent changes in the regulation of the low‐molecular‐mass GTP …
study differentiation‐dependent changes in the regulation of the low‐molecular‐mass GTP …
[HTML][HTML] A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophages
L Dmochewitz, C Förtsch, C Zwerger, M Vaeth… - PLoS …, 2013 - journals.plos.org
Background The C3bot1 protein (∼ 23 kDa) from Clostridium botulinum ADP-ribosylates
and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes …
and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes …
[图书][B] Probing the actin cytoskeleton by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin
K Aktories, U Prepens, P Sehr, I Just - 1997 - books.google.com
C. botulinum C2 toxin and C. perfringens iota toxin belong to the family of actin-ADP-
ribosylating toxins that transfer ADP-ribose from NAD to arginine-l77 of actin. This …
ribosylating toxins that transfer ADP-ribose from NAD to arginine-l77 of actin. This …
Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme
A Schröder, A Rohrbeck, I Just… - Journal of proteome …, 2015 - ACS Publications
C3bot from Clostridium botulinum is a bacterial mono-ADP-ribosylating enzyme, which
transfers an ADP-ribose moiety onto the small GTPases Rho A/B/C. C3bot and the catalytic …
transfers an ADP-ribose moiety onto the small GTPases Rho A/B/C. C3bot and the catalytic …
Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase.
W Wiegers, I Just, H Müller, A Hellwig… - European journal of …, 1991 - europepmc.org
The effects of Clostridium botulinum C3 ADP-ribosyltransferase and of Clostridium
botulinum C2 toxin were studied on the cytoskeleton of rat hepatoma FAO and human …
botulinum C2 toxin were studied on the cytoskeleton of rat hepatoma FAO and human …
[HTML][HTML] The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol
G Haug, J Leemhuis, D Tiemann, DK Meyer… - Journal of Biological …, 2003 - ASBMB
Clostridium botulinum C2 toxin is the prototype of the binary actin-ADP-ribosylating toxins
and consists of the binding component C2II and the enzyme component C2I. The activated …
and consists of the binding component C2II and the enzyme component C2I. The activated …