The protein toxin C3bot from Clostridium botulinum is a mono-ADP-ribosyltransferase that
selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and …

C3 exoenzymes (members of the ADP-ribosyltranferase family) are produced by Clostridium
botulinum (C3bot1 and-2), Clostridium limosum (C3lim), Bacillus cereus (C3cer), and …

It is well known tka; cc~ tnlr bacterial toxins, eg cholera and pertussis toxins. _4DP-ribosylate
euka yotic regulato y proteins. They have become invaluable tools in the study of G protein …

The culture medium of certain strains of Clostridium botulinum type C contains two
separable ADP-ribosyltransferases. Besides the ADP-ribosylation of actin due to botulinum …

Clostridium botulinum C2 toxin is an ADP‐ribosyltransferase, causing depolymerization of
the actin cytoskeleton in eukaryotic cells. The C2 toxin is a binary toxin consisting of the …

Botulinum C3 enzyme produced by Clostridium botulinum type C and D strains modifies
Rho proteins. In a previous study, we observed that the LDH isozyme pattern of neurons …

Clostridial organisms are an unusually rich source of biological substances that act on
eukaryotic cells (Simpson, 1989a). Many of these substances are noteworthy because of …

We demonstrated previously that monocytes and macrophages are target cells for the Rho-
modifying Clostridium botulinum C3 ADP-ribosyltransferase. Here, we report the …

Clostridium botulinum C2 toxin is a binary toxin composed of an enzymatic subunit (C2I)
capable of ADP-ribosylating actin and a binding subunit (C2II) that is responsible for …

Publisher Summary Clostridium botulinum (C. botulinum) is a rod-shaped, Gram positive,
sporulating, anaerobic bacillus that is widely distributed in the environment. The spores …