De-escalation of antimicrobial therapy in Gram-negative sepsis: easier said than done?
Methods All blood cultures analysed on the BD BACTEC system were evaluated over a 6-
week period (17 April 2010 to 30 May 2010). Organisms in positive blood cultures were then …
week period (17 April 2010 to 30 May 2010). Organisms in positive blood cultures were then …
Sepsis: Impact of timely and appropriate empirical antibiotic therapy on mortality
L Serpa-Pinto, T Cardoso - Critical Care, 2014 - Springer
Methods A retrospective cohort study including all adult patients with sepsis admitted to the
emergency room of a tertiary care, university hospital between 1 July 2011 and 30 June …
emergency room of a tertiary care, university hospital between 1 July 2011 and 30 June …
[HTML][HTML] Antibiotic prescription patterns in the empiric therapy of severe sepsis: combination of antimicrobials with different mechanisms of action reduces mortality
A Díaz-Martín, ML Martínez-González, R Ferrer… - Critical care, 2012 - Springer
Introduction Although early institution of adequate antimicrobial therapy is lifesaving in
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …
Challenges to implementation of sepsis guidelines
S Patel, E Wise, J Hartin, D Walker, M Noursadeghi - Critical Care, 2009 - Springer
Methods Two months after its introduction, the use of the SCR form was audited in all acute
medical admissions who met the clinical criteria for sepsis. One hundred sequential patients …
medical admissions who met the clinical criteria for sepsis. One hundred sequential patients …
[HTML][HTML] Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
FS Taccone, PF Laterre, T Dugernier, H Spapen… - Critical care, 2010 - Springer
Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …
serum β-lactam concentrations when standard dosages are administered. Previous studies …
ICU mortality rates in patients with sepsis before and after the Surviving Sepsis Campaign
J Melville, S Ranjan, P Morgan - Critical Care, 2015 - Springer
Methods A retrospective case note review was performed, looking at a sample of 5,954
patients who were 18 years or older who had been admitted to East Surrey Hospital (ESH) …
patients who were 18 years or older who had been admitted to East Surrey Hospital (ESH) …
[HTML][HTML] Time to treatment and mortality for clinical sepsis subtypes
A Yang, JN Kennedy, KM Reitz, G Phillips, KM Terry… - Critical Care, 2023 - Springer
Background Sepsis is common, deadly, and heterogenous. Prior analyses of patients with
sepsis and septic shock in New York State showed a risk-adjusted association between …
sepsis and septic shock in New York State showed a risk-adjusted association between …
[HTML][HTML] Factors influencing the implementation of antibiotic de-escalation and impact of this strategy in critically ill patients
L Gonzalez, A Cravoisy, D Barraud, M Conrad, L Nace… - Critical care, 2013 - Springer
Introduction A rational use of antibiotics is of paramount importance in order to prevent the
emergence of multidrug resistant bacteria that can lead to therapeutic impasse, especially in …
emergence of multidrug resistant bacteria that can lead to therapeutic impasse, especially in …
Employing quality improvement methodology in sepsis: an electronic sepsis order set further improves compliance with the Surviving Sepsis Campaign 3-hour bundle
S Rossi, A Shields, N Gauge, M Kinirons, A Hopper… - Critical Care, 2014 - Springer
Methods A retrospective cohort study in a university hospital was performed. Patients on
level 1 wards with severe sepsis registered in the adult critical care response team (CCRT) …
level 1 wards with severe sepsis registered in the adult critical care response team (CCRT) …
Medical microbiology ward rounds in critical care
L Wilson, G Dempsey - Critical Care, 2007 - Springer
Background Direct microbiological input to critical care is essential for the management of
the septic patient. Early broad-spectrum antimicrobial therapy with appropriate diagnostic …
the septic patient. Early broad-spectrum antimicrobial therapy with appropriate diagnostic …