We investigated the frequency of spontaneous apoptosis and expression of the Bcl-2 family
of proteins during normal spermatogenesis in man. Testicular tissue with both normal …

Using immunohistochemical techniques and Western blot analysis, the possible role of Bcl‐
2 family members Bax, Bcl‐2, Bcl‐xs, and Bcl‐xl in male germ cell density‐related apoptosis …

During normal spermatogenesis, more than half of the germ cells undergo apoptosis, but the
physiological significance and molecular mechanisms of this programmed cell death are …

Expression of bcl-w, a close relative of bcl-2 is essential for male fertility in mice. Although
the initial wave of spermatogenesis in bcl-w−/− mice proceeds normally until 3–4 weeks of …

Apoptosis occurs spontaneously during spermatogenesis. However, little is known about its
regulation in primate. Using an experimental cryptorchidism model in rhesus monkey, we …

A large part of germ cells die apoptotically during testicular development in rodents. In the
present study, a wave of germ cell apoptosis was observed between days 10 and 30 of …

Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice
that are mutant for Bclw display progressive and nearly complete testicular degeneration …

Bcl6 protein has been detected in testicular germ cells, mainly spermatocytes, of normal
mice, but its physiological role is largely unknown. The number of spermatozoa in the cauda …

To explore the functional role of Bcl‐2 in germ cell development, transgenic mice carrying 6
kilobases of the inhibin‐α promoter were generated to express human bcl‐2 gene product in …

Apoptosis and its augmentation by androgen withdrawal is an important event in the testis.
In other tissues apoptosis is regulated by genes belonging to the bcl-2 family. However, little …