[HTML][HTML] Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection
The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern
that waning immunity may predispose to reinfection. We analyzed the magnitude and …
that waning immunity may predispose to reinfection. We analyzed the magnitude and …
[HTML][HTML] Activation or exhaustion of CD8+ T cells in patients with COVID-19
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses
Although the protective role of neutralizing antibodies against COVID-19 is well established,
questions remain about the relative importance of cellular immunity. Using 6 pMHC …
questions remain about the relative importance of cellular immunity. Using 6 pMHC …
[HTML][HTML] Unbiased screens show CD8+ T cells of COVID-19 patients recognize shared epitopes in SARS-CoV-2 that largely reside outside the spike protein
AP Ferretti, T Kula, Y Wang, DMV Nguyen… - Immunity, 2020 - cell.com
Developing effective strategies to prevent or treat coronavirus disease 2019 (COVID-19)
requires understanding the natural immune response to severe acute respiratory syndrome …
requires understanding the natural immune response to severe acute respiratory syndrome …
[HTML][HTML] Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
T Sekine, A Perez-Potti, O Rivera-Ballesteros, K Strålin… - Cell, 2020 - cell.com
Summary SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune
protection against COVID-19. Here, we systematically mapped the functional and …
protection against COVID-19. Here, we systematically mapped the functional and …
Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age
M Humbert, A Olofsson, D Wullimann… - Proceedings of the …, 2023 - National Acad Sciences
Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed
individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide …
individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide …
Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome
SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory
tract disease (COVID-19). In some patients, the infection results in moderate to severe acute …
tract disease (COVID-19). In some patients, the infection results in moderate to severe acute …
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients
SK Saini, DS Hersby, T Tamhane, HR Povlsen… - Science …, 2021 - science.org
T cells are important for effective viral clearance, elimination of virus-infected cells, and long-
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …
[HTML][HTML] SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors
Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting
the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID …
the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID …
Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue
Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed …
(SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed …