Reactive T cells in convalescent COVID-19 patients with negative SARS-CoV-2 antibody serology

S Steiner, T Schwarz, VM Corman, F Sotzny… - Frontiers in …, 2021 - frontiersin.org
Despite RT-PCR confirmed COVID-19, specific antibodies to SARS-CoV-2 spike are
undetectable in serum in approximately 10% of convalescent patients after mild disease …

SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals

J Lang-Meli, H Luxenburger, K Wild, V Karl… - Nature …, 2022 - nature.com
Continuously emerging variants of concern (VOCs) sustain the SARS-CoV-2 pandemic. The
SARS-CoV-2 Omicron/B. 1.1. 529 VOC harbours multiple mutations in the spike protein …

Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19

S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

S Mahajan, V Kode, K Bhojak, C Karunakaran… - Scientific Reports, 2021 - nature.com
The COVID-19 pandemic has revealed a range of disease phenotypes in infected patients
with asymptomatic, mild, or severe clinical outcomes, but the mechanisms that determine …

CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19

V Mallajosyula, C Ganjavi, S Chakraborty… - Science …, 2021 - science.org
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …

HCoV-and SARS-CoV-2 cross-reactive T cells in CVID patients

S Steiner, F Sotzny, S Bauer, IK Na… - Frontiers in …, 2020 - frontiersin.org
The inability of patients with CVID to mount specific antibody responses to pathogens has
raised concerns on the risk and severity of SARS-CoV-2 infection, but there might be a role …

[HTML][HTML] SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity

JME Lim, AT Tan, N Le Bert, SK Hang… - Journal of Experimental …, 2022 - rupress.org
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+
and CD4+ T cells of broad specificity | Journal of Experimental Medicine | Rockefeller …

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

R Kundu, JS Narean, L Wang, J Fenn, T Pillay… - Nature …, 2022 - nature.com
Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic
cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 …

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19

AHE Roukens, CR Pothast, M König, W Huisman… - Nature …, 2022 - nature.com
Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are
extensively documented, but these are less well studied in the (upper) respiratory tract …

[HTML][HTML] Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants

C Hu, M Shen, X Han, Q Chen, L Li, S Chen, J Zhang… - Genes & diseases, 2022 - Elsevier
Despite the growing knowledge of T cell responses in COVID-19 patients, there is a lack of
detailed characterizations for T cell-antigen interactions and T cell functions. Here, with a …